Bone morphogenetic protein 15 (BMP-15) is a protein that in humans is encoded by the BMP15 gene. It is involved in folliculogenesis, the process in which primordial follicles develop into pre-ovulatory follicles.

Dec 24, 2024 · BMP15 (Bone Morphogenetic Protein 15) is a Protein Coding gene. Diseases associated with BMP15 include Ovarian Dysgenesis 2 and 46 Xx Gonadal Dysgenesis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.

骨形态发生蛋白-15 (bonemorphogenetic protein-15， BMP-15) 是近年来备受关注的卵母细胞源性生长因子之一。 Hosoe等报道BMP-15在牛的卵母细胞和卵丘细胞中均有表达， 且在母牛卵丘细胞中的表达水平显著高于小牛。 在小鼠卵巢中， BMP-15最早出现于初级卵泡中， 持续表达于卵泡晚期， 并维持至排卵后12hrs。 在不同年龄妇女的卵巢中， 均可检测到BMP-15的表达， 特别是在原始卵泡期， 但性腺外组织中尚未见。 在卵泡发育过程中， BMP-15在前期呈低水平表达， 排 …

Bone morphogenetic protein 15 (BMP15) acts as a BMP and Wnt inhibitor during early embryogenesis. These findings support the concept that an adequate amount of BMP15 secreted in the follicular fluid is critical for female fertility. BMP15 variants do not play a significant role in human dizygotic twinning.

形态发生蛋白 15 (bmp-15;gdf9b) 又称生长分化因子 9b (gdf9b)，是 tgfβ 家族的一种多效配体蛋白，仅在卵泡细胞中表达。bmp15 与 gdf9 密切相关，gdf9则参与早期卵泡发生，有至关重要的作用。bmp15 和 gdf9 参与了卵泡发育的遗传调控。

Nov 2, 2024 · Title: Bone morphogenetic protein 15 induces differentiation of mesenchymal stem cells derived from human follicular fluid to oocyte-like cell. Fundamental role of BMP15 in human ovarian folliculogenesis revealed by null and missense mutations associated with …

Bone Morphogenetic Protein-15 (BMP15) is an oocyte-derived growth factor belonging to the Transforming Growth Factor-beta (TGF-β) superfamily which is involved in follicular development as critical regulator of many granulosa cell processes [48–52].

Nov 2, 2024 · Bone morphogenetic protein 15 (BMP15) acts as a BMP and Wnt inhibitor during early embryogenesis. Di Pasquale E, Brivanlou AHDi Pasquale E, et al. J Biol Chem, 2009 Sep 18. PMID 19553676. Sequence variants in exons of the BMP-15 gene in Chinese patients with premature ovarian failure.

该基因编码 TGF-β (转化生长因子-β) 蛋白质超家族的分泌配体。 该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。 编码的前原蛋白经过蛋白水解处理，生成二硫键连接的同二聚体亚基，或者异二聚体，以及相关蛋白生长分化因子 9 (GDF9) 。 这种蛋白质通过激活颗粒细胞在卵母细胞成熟和卵泡发育中发挥作用。 该基因的缺陷是卵巢发育不全的原因，并与卵巢早衰有关。 [RefSeq 提供，2016 年 8 月] This gene encodes a secreted …

Dec 16, 2023 · Bone morphogenetic protein (BMP15) and growth differentiation factor (GDF9) are critical for ovarian follicular development and fertility and are associated with litter...