The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the BCR gene. BCR is one of the two genes in the BCR-ABL fusion protein, which is associated with the Philadelphia chromosome.

Dec 24, 2024 · Complete information for BCR gene (Protein Coding), BCR Activator Of RhoGEF And GTPase, including: function, proteins, disorders, pathways, orthologs, and expression.

The BCR gene provides instructions for making a protein whose function is not completely understood. Studies show that the BCR protein may act as a GTPase activating protein (GAP). GAPs turn off (inactivate) proteins called GTPases, which play an important role in chemical signaling within cells.

This review explores the mechanisms behind cancer progression of these BCR oncogenic fusion proteins, comparing their similarities and differences, examining the significance of BCR as a partner gene, and discussing current treatment options for these translocation-induced hematopoietic malignancies.

Bcr-abl regulates number of biological processes such as cell propagation, cell survival and cell trafficking. Importantly, overexpression of Bcr-abl induces chemo-resistance in CML [174]. Thus BCR-abl could be an essential therapeutic target in AML, ALL, and CML treatment [174].

Feb 8, 2025 · The ABL gene was inserted into the BCR region of chromosome 22 in chronic myelogenous leukemia. The molecular breakpoint of the BCR-ABL fusion gene has been characterized for 122 chronic myeloid leukemia patients.

Dec 20, 2023 · Bcr gene is a gene that plays a crucial role in the development of chronic myelogenous leukemia and is the target of a revolutionary drug called imatinib, which has significantly improved the prognosis for patients with this type of cancer.

Mar 3, 2001 · Recent investigations have rapidly added crucial new insights into the complex functions of the normal BCR gene and of the BCR-ABL chimera and are yielding potential therapeutic breakthroughs in the treatment of Philadelphia (Ph) chromosome-positive leukemias.

Breakpoint cluster region (BCR) is a gene that functions as a fusion partner with ABL1 to encode a fusion protein that is a result of the reciprocal translocation between chromosomes 22 and 9. The translocation produces the Philadelphia chromosome - a hallmark feature of chronic myelogenous leukemia (CML).

A genetic rearrangement (translocation) involving the BCR gene causes a type of cancer of blood-forming cells called chronic myeloid leukemia. This slow-growing cancer leads to an overproduction of abnormal white blood cells.