The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the BCR gene. BCR is one of the two genes in the BCR-ABL fusion protein, which is associated with the Philadelphia chromosome. Two transcript variants encoding different isoforms have been found for this gene.

2024年12月24日 · BCR (BCR Activator Of RhoGEF And GTPase) is a Protein Coding gene. Diseases associated with BCR include Leukemia, Chronic Myeloid and B-Lymphoblastic Leukemia/Lymphoma With T(9;22)(Q34.1;Q11.2) . Among its related pathways are Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics and RHOC GTPase cycle .

A genetic rearrangement (translocation) involving the BCR gene causes a type of cancer of blood-forming cells called chronic myeloid leukemia. This slow-growing cancer leads to an overproduction of abnormal white blood cells.

2023年12月20日 · Bcr gene is a gene that plays a crucial role in the development of chronic myelogenous leukemia and is the target of a revolutionary drug called imatinib, which has significantly improved the prognosis for patients with this type of cancer.

This review explores the mechanisms behind cancer progression of these BCR oncogenic fusion proteins, comparing their similarities and differences, examining the significance of BCR as a partner gene, and discussing current treatment options for these translocation-induced hematopoietic malignancies.

The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint.

The ABL1 gene from chromosome 9 fuses with the BCR gene on chromosome 22. BCR stands for “break point cluster region.” ABL1 is an oncogene. The Philadelphia chromosome is present in 90–95% of cases of CML. In the Philadelphia chromosome negative cases, the BCR–ABL1 fusion gene can be detected by FISH, PCR, or Southern blot techniques.