Dec 24, 2024 · BCL11B (BCL11 Transcription Factor B) is a Protein Coding gene. Diseases associated with BCL11B include Intellectual Developmental Disorder With Speech Delay, Dysmorphic Facies, And T-Cell Abnormalities and Immunodeficiency 49, Severe Combined .

B cell leukemia 11b (Bcl11b) is a zinc finger protein transcription factor with a multiplicity of functions. It works as both a genetic suppressor and activator, acting directly, attaching to promoter regions, as well as indirectly, attaching to promoter-bound transcription factors.

Mar 12, 2024 · The transcription factor BCL11B plays an essential role in the development of central nervous system and T cell differentiation by regulating the expression of numerous genes involved in several...

Mar 12, 2021 · The BCL11B gene, encoding a transcription factor (TF) essential for T cell development and function, was the most extensively regulated, with expression increasing throughout NK cell differentiation. Several Bcl11b-regulated genes associated with T cell signaling were specifically expressed in adaptive NK cell subsets.

Sep 2, 2021 · Recent findings on lineage-promiscuous acute leukemia reveal the BCL11B locus as a multiheaded beast that can drive a variety of immature leukemias, including undifferentiated acute leukemia (AUL), minimally differentiated acute myeloid leukemia (AML M0/M1), mixed-phenotype acute leukemia with T myeloid features (T/M MPAL), early thymic progenit...

Using massively parallel sequencing we identified 13 patients bearing heterozygous germline alterations in BCL11B. Notably, all of them are affected by global developmental delay with speech impairment and intellectual disability; however, none displayed overt clinical signs of immune deficiency.

Feb 9, 2025 · BCL11B suppresses tumor progression and stem cell traits in hepatocellular carcinoma by restoring p53 signaling activity. Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB1 receptors. BCL11B regulates MICA/B-mediated immune response by acting as a competitive ...

Dec 10, 2024 · Title: BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells. BCL11B Upregulates the Expression of RelA in T Cells Stimulated with Staphylococcal Enterotoxin A.

Feb 24, 2017 · Our studies show BCL11B is a key regulator of the initial stages of human T-cell differentiation and delineate the BCL11B transcriptional program, enabling the dissection of the...

B‐cell lymphoma/leukaemia 11B (BCL11B) is an essential transcriptional regulator of T cells and is engaged in regulating vital biological processes including T‐cell development, proliferation, differentiation and survival. 1, 2 Previous studies have shown that BCL11B exhibits abnormally high expression levels in cases of T‐cell acute ...