β 2 microglobulin (B2M) is a component of MHC class I molecules. MHC class I molecules have α 1, α 2, and α 3 proteins which are present on all nucleated cells (excluding red blood cells). [5] [6] In humans, the β 2 microglobulin protein [7] is encoded by the B2M gene. [6] [8]

A beta-2 microglobulin (B2M) tumor marker test usually measures the amount of B2M in your blood. It can help find out how serious your cancer may be. Learn more.

Beta-2 microglobulin is a blood, urine or cerebrospinal fluid test to help stage a disease (an elevated B2M may indicate metastasis) and monitor treatment response.

Dec 24, 2024 · Complete information for B2M gene (Protein Coding), Beta-2-Microglobulin, including: function, proteins, disorders, pathways, orthologs, and expression.

Aug 29, 2024 · Beta-2 microglobulin (B2M) is a cell surface protein that checks for cancer cell growth. It’s known as a tumor marker; it indicates that the cell is inflamed or performing abnormally. It can be found in blood or urine, and its discovery can indicate different diseases. When CLL cells replicate, they release B2M into the blood.

Beta-2-microglobulin (B2M) is a protein that is found on the surface of almost all cells in the body and is shed by cells into the blood, particularly by B lymphocytes and tumour cells. It is present in most body fluids and its level rises with conditions that increase cell production and/or destruction, or that activate the immune system.

Feb 11, 2021 · Beta-2 microglobulin (B2M), used as a tumor marker, is high in multiple myeloma or other types of cancer (lymphoma, leukemia, etc.).

A serum beta-2-microglobulin (beta-2-M) value of less than 4 mcg/mL is a good prognostic factor in patients with multiple myeloma. In a study of pretreatment serum beta-2-M levels in 100 patients with myeloma, it was reported that the median survival of patients with values greater than 4 mcg/mL was 12 months, whereas median survival for patients with values less than 4 …

Feb 9, 2025 · Title: Plasma Proteomics Identifies B2M as a Regulator of Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction.

Oct 1, 2021 · B2M, an important subunit of the MHC class I molecule, has diverse functions in physiological and pathological conditions both in tumor cells and non-tumor cells, especially playing an important role in immune surveillance. B2M mutations have been identified in considerable cancer patients.