A collection of methods to predict linear B cell epitopes based on sequence characteristics of the antigen using amino acid scales and HMMs.

B-cell epitope prediction aims to facilitate B-cell epitope identification with the practical purpose of replacing the antigen for antibody production or for carrying structure-function studies. Any solvent-exposed region in the antigen can be subject of recognition by antibodies.

2022年8月12日 · Prediction of B cell epitopes that can replace the antigen for antibody production and detection is of great interest for research and the biotech industry. Here, we developed a novel...

Ras-Carmona A, Pelaez-Prestel HF, Lafuente EM, Reche PA. BCEPS: A Web Server to Predict Linear B Cell Epitopes with Enhanced Immunogenicity and Cross-Reactivity. Cells. 2021 Oct 14;10 (10):2744. doi: 10.3390/cells10102744. PMID: 34685724; PMCID: PMC8534968.

2024年11月11日 · In this study, we present EpiGraph, which harnesses feature embedding from pretrained protein models and the graph attention network (GAT) model to capture B cell epitope properties.

Prediction of B cell epitopes that can replace the antigen for antibody production and detection is of great interest for research and the biotech industry. Here, we developed a novel BLAST-based method to predict linear B cell epitopes.

The identification and characterization of B-cell epitopes play an important role in vaccine design, immunodiagnostic tests, and antibody production. Therefore, computational tools for reliably predicting linear B-cell epitopes in protein sequences are highly desirable.

2023年1月5日 · To advance the field of B-cell epitope prediction, we have benchmarked and analyzed some of the most popular generic and antibody-specific B-cell epitope prediction methods by testing whether they are able to accurately identify experimentally validated epitopes.

2024年1月30日 · In this work, we developed the new linear BCE prediction method LBCE-BERT. This method is based on peptide chain sequence information and natural language model BERT embedding information,...

Predict of B-cell epitopes (antigenic region) with high accuracy is one of the major challenges in designing subunit/peptide vaccine or immunotherapy. In past number of methods have been developed for predicting linear or continious B-cell epitopes like ABCpred.