BRAF Mutation and Cancer - Johns Hopkins Medicine
A BRAF mutation is a spontaneous change in the BRAF gene that makes it work incorrectly. A mutation causes the gene to turn on the protein and keep it on, which means certain cells get …
BRAF Mutation: Cancer Types, Testing, Treatment - Verywell Health
Jun 23, 2024 · BRAF mutations are DNA changes in some cancer cells that can be treated with newer targeted therapies. BRAF mutations are found in roughly half of melanomas. …
BRAF (gene) - Wikipedia
BRAF is a human gene that encodes a protein called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B, while the protein is …
Emerging BRAF Mutations in Cancer Progression and Their …
In the human genome, the B-raf proto-oncogene (BRAF) gene is located on chromosome 7 (7q34) and encodes the BRAF protein, which is composed of 766 amino acids. While all RAF …
BRAF and Lung Cancer - American Lung Association
BRAF is one type of lung cancer biomarker. BRAF is the name of both a gene and a protein. The BRAF protein helps control cell growth. When there is a mutation in the BRAF gene, it creates …
FDA approves dabrafenib–trametinib for BRAF-positive cancers
Jul 21, 2022 · Data from NCI-MATCH, ROAR trials informed approval Dabrafenib and trametinib block different growth-promoting signals in tumor cells that are activated by the V600E BRAF …
BRAF — a tumour-agnostic drug target with lineage-specific
Jan 26, 2024 · In this Review, we describe the biochemical basis for oncogenic BRAF-induced activation of MAPK signalling and pan-cancer and lineage-specific mechanisms of intrinsic, …
BRAF B-Raf proto-oncogene, serine/threonine kinase [ (human)]
Gene ID: 673, updated on 8-Feb-2025. This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK …
Molecular Pathways and Mechanisms of BRAF in Cancer Therapy
In this review, we identify the mechanics of RAF signaling through the RAS/MAPK pathway, present existing data on single-agent and combination RAF targeting efforts, describe …
BRAF Gene - GeneCards | BRAF Protein | BRAF Antibody
Dec 24, 2024 · BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with BRAF include Lung Cancer and Cardiofaciocutaneous …