A BRAF mutation is a spontaneous change in the BRAF gene that makes it work incorrectly. A mutation causes the gene to turn on the protein and keep it on, which means certain cells get …

BRAF is a human gene that encodes a protein called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B , while the protein is …

In the human genome, the B-raf proto-oncogene (BRAF) gene is located on chromosome 7 (7q34) and encodes the BRAF protein, which is composed of 766 amino acids. While all RAF …

2024年6月23日 · BRAF mutations are DNA changes in some cancer cells that can be treated with newer targeted therapies. BRAF mutations are found in roughly half of melanomas. …

2024年4月16日 · In this review, we cover the current understanding of BRAF mutations and associated clinical characteristics in patients with metastatic NSCLC, approved and emerging …

2024年1月26日 · In this Review, we describe the biochemical basis for oncogenic BRAF-induced activation of MAPK signalling and pan-cancer and lineage-specific mechanisms of intrinsic, …

In this review, we identify the mechanics of RAF signaling through the RAS/MAPK pathway, present existing data on single-agent and combination RAF targeting efforts, describe …

Gene ID: 673, updated on 8-Feb-2025. This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK …

2024年12月24日 · BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with BRAF include Lung Cancer and Cardiofaciocutaneous …

2025年2月28日 · BRAF (V-Raf murine sarcoma viral oncogene homolog B) mutation is an uncommon mutation. Mutated BRAF proteins cause cells to grow out of control. This can …

B-Raf is a key regulator of the ERK pathway and is mutationally activated in two-thirds of human melanomas. In this work, we have investigated the activation mechanism of B-Raf and …

B-Raf is one of the more commonly mutated proto-oncogenes implicated in the development of cancers. In this review, we consider the mechanisms and clinical impacts of B-Raf mutations …

2019年2月26日 · BRAF encodes the B-Raf protein, which is involved in signal transduction inside cells. It catalyzes phosphorylation of serine and threonine on target proteins, converting …

B-raf, a new member of the raf family, is activated by DNA rearrangement. Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with …

BRAF is one type of lung cancer biomarker. BRAF is the name of both a gene and a protein. The BRAF protein helps control cell growth. When there is a mutation in the BRAF gene, it creates …

B-Raf. Genes of the Raf family mediate cellular response to growth signals. Genetic and biochemical evidence indicates that B-Raf is the principal downstream effector of K-Ras. …

2012年12月3日 · Vemurafenib is the first molecularly targeted therapy to be licensed in the US and Europe for treatment of advanced melanoma. Its mechanism of action involves selective …

2002年12月1日 · BRAF encodes a RAS-regulated kinase that mediates cell growth and malignant transformation kinase pathway activation. Recently, we have identified activating BRAF …

2025年3月7日 · Targeted Oncology: Please explain the background, methods, and design of the BREAKWATER trial. Kopetz: The BREAKWATER study was a randomized phase 3 study that …

Approximately 50% of melanomas harbor activating (V600) mutations in the serine–threonine protein kinase B-RAF (BRAF). The oral BRAF inhibitor vemurafenib (PLX4032) frequently …