Transcriptional regulator ATRX also known as ATP-dependent helicase ATRX, X-linked helicase II, or X-linked nuclear protein (XNP) is a protein that in humans is encoded by the ATRX gene. [5][6][7] Transcriptional regulator ATRX contains an ATPase / helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins.

Dec 24, 2024 · ATRX (ATRX Chromatin Remodeler) is a Protein Coding gene. Diseases associated with ATRX include Alpha-Thalassemia Myelodysplasia Syndrome and Intellectual Disability-Hypotonic Facies Syndrome, X-Linked, 1. Among its related pathways are Alternative Lengthening of Telomeres (ALT) and Chromosome Maintenance.

The ATRX gene provides instructions for making a protein that plays an essential role in normal development. Although the specific function of the ATRX protein is unknown, studies suggest that it helps regulate the activity (expression) of other genes through a …

ATRX is one of the most frequently mutated tumor suppressor genes in human cancers. ATRX protein is a chromatin remodeler and transcriptional regulator that is essential for normal development. ATRX plays a crucial role in several essential cellular ...

ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated tumor suppressor genes in human cancers, especially in glioma, and recent findings indicate roles for ATRX in key molecular pathways, such as the regulation of chromatin state, gene expression, and DNA damage …

Jun 23, 2021 · Occurs in pediatric and adult high grade astrocytoma (Mod Pathol 2013;26:1425) Alternative Lengthening of Telomeres (ALT) is a non-telomerase mechanism of telomere lengthening that occurs in ~10% of cancers overall and is particularly common in astrocytic brain tumors; ATRX may be a repressor of ALT (PLoS One 2012;7:e50062, Oncotarget 2012;3: ...

Jan 25, 2024 · Stimulating the innate immune system has been explored as a therapeutic option for the treatment of gliomas. Inactivating mutations in ATRX, defining molecular alterations in IDH -mutant...

Jun 23, 2021 · ATRX is a tumor suppressor that has been associated with protection from DNA replication stress, purportedly through resolution of difficult-to-replicate G-quadruplex (G4) DNA structures.

Mar 7, 2023 · ATRX is a central player regulating the DNA damage response and prevents chromosomal instability. ATRX limits the formation of secondary structures that can trigger replication fork stalling and replication stress. Furthermore, ATRX regulates DNA repair via homologous recombination.

Jun 1, 2023 · ATRX is a central player regulating the DNA damage response and prevents chromosomal instability. ATRX limits the formation of secondary structures that can trigger replication fork stalling and replication stress. Furthermore, ATRX regulates DNA repair via homologous recombination.