
Low-density lipoprotein receptor-related protein 8 - Wikipedia
Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein that in humans is encoded by the LRP8 gene. [5][6][7] ApoER2 is a cell surface receptor that is part of the low-density lipoprotein receptor family.
VLDLR and ApoER2 are receptors for multiple alphaviruses
2021年12月20日 · We show that the E2 and E1 glycoproteins (E2–E1) of Semliki forest virus, eastern equine encephalitis virus and Sindbis virus interact with the ligand-binding domains (LBDs) of VLDLR and...
ApoER2 (Apolipoprotein E Receptor-2) Deficiency Accelerates …
2019年8月15日 · Genome-wide studies showed that mutation in apoER2 (apolipoprotein E receptor-2) is additive with ε4 polymorphism in the APOE gene on cardiovascular disease risk in humans. ApoE or apoER2 deficiency also accelerates atherosclerosis lesion necrosis in hypercholesterolemic mice and promotes neointima formation after vascular injury.
The Reelin Receptors Apolipoprotein E receptor 2 (ApoER2) and …
Apolipoprotein E receptor 2 (ApoER2) and VLDL receptor belong to the low density lipoprotein receptor family and bind apolipoprotein E. These receptors interact with the clathrin machinery to mediate endocytosis of macromolecules but also interact ...
ApoER2: Functional Tuning Through Splicing - PMC - PubMed …
Apolipoprotein E receptor 2 (apoER2) is a critical modulator of neuronal development and synaptic plasticity in the brain and is enriched in cassette exon splicing events, in which functional exons are excluded from the final transcript.
Similarities and differences in structure, expression, and functions …
Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) are important receptors in the brain for mediating the signaling effects of the extracellular matrix protein Reelin, affecting neuronal function in development and in the adult brain.
Apoer2/Lrp8: the undercover cop of synaptic homeostasis : Neural ... - LWW
Apolipoprotein E receptor 2 (ApoER2) is a receptor for the protein ApoE, the most common genetic risk factor for late-onset Alzheimer’s disease (AD). It is also a key modulator of synaptic homeostasis, in part through its effect on the expression of neuronal genes including those implicated in AD and other neuropsychiatric disorders.
Human APOER2 Isoforms Have Differential Cleavage Events and …
2022年5月18日 · APOER2 undergoes proteolytic cleavage in response to ligand binding that releases a C-terminal fragment (CTF) and transcriptionally active intracellular domain (ICD). We tested whether the diversity of human brain-specific APOER2 variants affects APOER2 cleavage.
ApoER2: Functional Tuning Through Splicing - PubMed
2020年7月31日 · Apolipoprotein E receptor 2 (apoER2) is a critical modulator of neuronal development and synaptic plasticity in the brain and is enriched in cassette exon splicing events, in which functional exons are excluded from the final transcript.
ApoER2 (Apolipoprotein E Receptor-2) Deficiency Accelerates …
Objective: Genome-wide studies showed that mutation in apoER2 (apolipoprotein E receptor-2) is additive with ε4 polymorphism in the APOE gene on cardiovascular disease risk in humans. ApoE or apoER2 deficiency also accelerates atherosclerosis lesion necrosis in hypercholesterolemic mice and promotes neointima formation after vascular injury.