Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin and RING subunit much like SCF.

The separation of sister chromatids at anaphase, which is regulated by an E3 ubiquitin ligase called the anaphase-promoting complex/cyclosome (APC/C), is arguably the most important irrevocable event during the cell cycle. The APC/C and ...

We summarize the current state of knowledge regarding APC/C structure and function, as well as the distinct ways Cdh1 and Cdc20 are dysregulated in human cancer. We also discuss APC/C inhibitors, novel approaches for targeting the APC/C as a …

2015年6月15日 · The anaphase-promoting complex (APC/C) is a multimeric RING E3 ubiquitin ligase that controls chromosome segregation and mitotic exit.

Here, we discuss the most recent developments in the APC/C field concerning structure, substrate recognition, and catalysis. Keywords: Ubiquitination, anaphase-promoting complex, spindle assembly checkpoint, mitosis, cyclosome, phosphorylation, electron microscopy.

2016年7月13日 · This review will aim to summarize some recently reported insights into APC/C in regulating cellular function, connection of its dysfunction with human diseases and its implication of therapeutics.

2006年8月9日 · The anaphase promoting complex/cyclosome (APC/C) is a 1.5-MDa ubiquitin ligase complex that initiates sister-chromatid separation and exit from mitosis by targeting cyclin B and securin...

2006年6月15日 · The APC/C associates with activators from the Cdc20/Fizzy (Fzy) and Cdh1/Fizzy-related (Fzr) families in a cell-cycle-dependent manner. These activators are WD40 proteins and interact with the APC/C, potentially with APC3 and/or APC7.

2019年5月23日 · The separation of sister chromatids at anaphase, which is regulated by an E3 ubiquitin ligase called the anaphase-promoting complex/cyclosome (APC/C), is arguably the most important irrevocable event during the cell cycle.

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