Alpha secretases are a family of proteolytic enzymes that cleave amyloid precursor protein (APP) in its transmembrane region. Specifically, alpha secretases cleave within the fragment that …

Ectodomain shedding of the amyloid precursor protein (APP) by the metalloprotease activity α-secretase is a key regulatory event preventing the generation of the Alzheimer's disease (AD) …

α-Secretase, β-secretase and γ-secretase are proteases that control the production of amyloid-β (Aβ) in the brain. The secretases represent the most promising drug targets for Alzheimer …

Here we review research efforts that have attempted to inhibit the generation of the beta amyloid peptide through modulation of the activity of the proteolytic secretases that act on the amyloid …

The α-secretase cuts the extracellular domain closer to the membrane, leaving 12 amino acids on the external surface. This results in the “constitutive” secretion of the large extracellular …

Alpha secretase is an enzyme that competes with BACE-1 for cleavage of the amyloid precursor protein (APP), leading to the secretion of a neurotrophic factor called APPs-alpha, which is …

Protein kinase C and mitogen-activated protein kinase constitute central signaling hubs for the regulation of α-secretase cleavage. Additionally, recent studies increasingly demonstrate that …

Jan 1, 2012 · Inhibitors or modulators that target beta- and gamma-secretases as well as alpha-secretase activators are promising candidates for treatment of Alzheimer's disease. A deep …

ADAM10 is the main α-secretase that cleaves APP (amyloid precursor protein) in the non-amyloidogenic pathway inhibiting the formation of β-amyloid peptide, whose accumulation and …

Three proteases that are involved in the processing of amyloid precursor protein—α-secretase, β-secretase and γ-secretase—are of particular interest as they are central to the generation and...