Allostatic load is "the wear and tear on the body" which accumulates as an individual is exposed to repeated or chronic stress. The term was coined by Bruce McEwen and Eliot Stellar in 1993.

2022年8月11日 · What Is Allostatic Load? Allostatic load refers to the cumulative effects that chronic stress has on mental and physical health. More simply, it refers to the 'wear and tear' on the body that life events and environmental stressors create.

The findings indicate that allostatic load and overload are associated with poorer health outcomes. Assessment of allostatic load provides support to the understanding of psychosocial determinants of health and lifestyle medicine.

Allostatic load is a physiological measure of the cumulative burden of stress on the body assessed by markers of physiological dysregulation. It is a multisystem construct that quantifies biological risk which leads to poor health and maladaptive trajectories.

2024年8月18日 · At its core, allostatic load is the cumulative wear and tear on the body’s systems as they strive to maintain balance in response to ongoing stressors. To fully grasp this concept, we must first understand the relationship between allostasis and homeostasis.

2020年10月26日 · Allostatic overload occurs when the cumulative effects of physiological stress response lead to health problems, disease, or death. This is why it’s estimated that...

Allostatic load is a measure of physiological dysregula-tion due to the cumulative burden of chronic stress on the body. This dysregulation is caused by the excess secretion of hormones such as catecholamines and glu-cocorticoids in response to chronic stressors.

In allostatic load, it is the accumulation over time of the “wear and tear on a number of organs and tissues” that leads to physiological dysregulation and ultimately, via allostatic overload, to physical or mental illness.

Allostatic load represents physiological dysregulations related to chronic stress that progressively disrupts interconnected neuroendocrine, immune, metabolic, and cardiovascular biomarkers in a multisystemic cascade (McEwen, 1998).

Allostatic load is a multisystem construct theorized to quantify stress-induced biological risk. Differences in allostatic load may reflect differences in stress exposure and thus provide a mechanistic link to understanding health disparities.