2024年12月24日 · This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in …

2021年10月1日 · Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166) is a glycoprotein involved in homotypic and heterotypic cell adhesion. ALCAM can be proteolytically cleaved at the cell surface by metalloproteases, which generate shedding of its ectodomain.

Gene ID: 214, updated on 8-Feb-2025. This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain.

CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene. [5][6] It is also called CD166 (cluster of differentiation 166), MEMD, [7] SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat.

2020年8月1日 · Activated leukocyte cell adhesion molecule (ALCAM) or CD166 is a 100 to 105 KDa transmembrane immunoglobulin which is involved in activation of T-cells, hematopoiesis, neutrophils trans-endothelial migration, angiogenesis, inflammation and tumor propagation and invasiveness through formation of homophilic and heterophilic interactions.

ALCAM functions as a cell–cell adhesion molecule and engages in homotypic (ALCAM–ALCAM) and heterotypic (ALCAM–CD6) interactions between adjacent cells. These interactions are mediated through its most amino-terminal V domain (D1).

活化白细胞粘附分子（ALCAM）或CD166是一种100至105 KDa的跨膜免疫球蛋白，与T细胞活化，造血，嗜中性粒细胞跨内皮迁移，血管生成，炎症和肿瘤扩散以及通过形成亲和异源性而侵入互动。 最近，许多研究提出ALCAM的表达模式与肿瘤的等级，阶段和侵袭性高度相关。 尽管ALCAM是不同癌症中有价值的预后标志物，但是不同肿瘤类型中相似的表达模式可能与完全不同的预后状态相关，使其成为依赖肿瘤类型的预后标志物。 另外，ALCAM同工型为初步检测具有 …

Share your videos with friends, family, and the world

Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166) is a cell–cell adhesion protein conferring heterotypic and homotypic interactions between cells of the same type and different types. It is aberrantly expressed in various cancer types and has been shown to be a regulator of cancer metastasis.

G&M NEUROCOSMEDICS is an australia trademark and brand of Alcamm Holdings Pty Ltd, NSW 2140,AUSTRALIA. This trademark was filed to IP Australia on Thursday, February 4, 2016.