2024年12月24日 · AKT2 (AKT Serine/Threonine Kinase 2) is a Protein Coding gene. Diseases associated with AKT2 include Hypoinsulinemic Hypoglycemia With Hemihypertrophy and Akt2-Related Familial Partial Lipodystrophy .

2025年2月8日 · AKT2 drives cancer progression and is negatively modulated by miR-124 in human lung adenocarcinoma. A novel miRNA located in the GATA4 gene regulates the expression of IGF-1R and AKT1/2 genes and controls cell proliferation. miR-664b-5p Inhibits Hepatocellular Cancer Cell Proliferation Through Targeting Oncogene AKT2.

AKT is a central protein in many cellular pathways such as cell survival, proliferation, glucose uptake, metabolism, angiogenesis, as well as radiation and drug response. The three isoforms of AKT (AKT1, AKT2 and AKT3) are proposed to have different ...

Activated AKT2, which is primarily expressed in insulin-responsive tissues, promotes translation of glucose transporter 4 (GLUT4). And the direct target of AKT is a substrate of 160 kDa (AS160), also known as TBC1D1 29 .

2025年2月8日 · Title: Active AKT2 stimulation of SREBP1/SCD1-mediated lipid metabolism boosts hepatosteatosis and cancer. m 6 A reader IGF2BP1 reduces the sensitivity of nasopharyngeal carcinoma cells to Taxol by upregulation of AKT2.

Akt, also known as Protein kinase B (PKB), is a serine-threonine kinase with important roles in proliferation, metabolism, cell differentiation, survival, etc (1, 2). There are three distinct Akt isoforms encoded by three separate genes, namely Akt1/PKBα, Akt2/PKBβ and Akt3/PKBγ.

AKT2 is a serine/threonine kinase that is an effector molecule in the insulin signaling pathway linked to insulin’s metabolic effects.

2020年12月16日 · Akt2 loss-of-function increased anxiety-like phenotypes, impaired fear conditioned learning, social behaviors and discrimination memory. Reduced sensitivity to amphetamine was observed,...

2025年3月3日 · SC79 activated AKT1, AKT2, and AKT3, translocated a disintegrin and metalloprotease 10 (ADAM10) to the cell surface, and induced ectodomain shedding of the receptor for AGEs (RAGE). In contrast ...

2020年9月18日 · Our study establishes a new and important function of AKT2 in regulating skeletal muscle development and glucose metabolism via AMPK-dependent signaling. Keywords: AKT2; AMPK; glucose metabolism; mitochondria; skeletal muscle.