Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors.

Dec 24, 2024 · ACVR2A (Activin A Receptor Type 2A) is a Protein Coding gene. Diseases associated with ACVR2A include 2Q23.1 Microduplication Syndrome and Fibrodysplasia Ossificans Progressiva. Among its related pathways are Signaling by TGFB family members and Signaling by NODAL.

Nov 6, 2024 · 1. acvr2a与acvr2b概述. acvr2a（激活素受体2a）和acvr2b（激活素受体2b）是转化生长因子β（tgf-β）受体超家族中的两个重要成员，作为激活素a的ii型受体，它们在细胞生长、分化和组织修复等多种生理过程中发挥关键作用。

Feb 8, 2025 · Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway. Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2. Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer.

Sep 13, 2023 · Sotatercept 是一款潜在 “first-in-class”IIA 型激活素受体（ ACVR2A ）融合蛋白，可将 ACVR2A 经过改造的细胞外域与抗体的 Fc 端融合在一起，阻断激活素与细胞膜上的受体结合，从而降低激活素介导的信号传导。

ACVR2A, also known as Activin RIIA, is an activin type II receptor. On ligand binding, ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. ACVR2A is a receptor for Activin A, Activin B and Inhibin A.

该基因编码的受体介导激活素的功能，激活素是参与多种生物过程的转化生长因子-β (TGF-β) 超家族的成员。 编码的蛋白质是一种跨膜丝氨酸-苏氨酸激酶受体，它通过以细胞特异性方式与 I 型和 II 型受体和配体的各种组合形成异二聚体复合物来介导信号传导。 编码的 II 型受体主要参与配体结合，包括细胞外配体结合结构域、跨膜结构域和细胞质丝氨酸-苏氨酸激酶结构域。 该基因可能与先兆子痫的易感性有关，先兆子痫是一种与妊娠相关的疾病，可导致母体和胎儿的发病率和死亡 …

用于研究Weissenbacher-Zweymuller综合征。 这种基因的人类同源物与结肠癌有关。 与人类的ACVR2A（激活素A受体2A）正交。 [由基因组资源联盟，2022年4月提供] Dir./Indir. Functional annotation of a full-length mouse cDNA collection. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

Feb 8, 2025 · Clinical resource with information about ACVR2A, Genome-wide association analyses identify 18 new loci associated with serum urate concentrations., Genome-wide association of lipid-lowering response to statins in combined …

该基因编码的蛋白可启动多种功能，包括 BMP 受体活性； PDZ 域绑定活动；和激活素结合活性。 作用于多个过程的上游或内部，包括支持细胞增殖；交配;和胚胎骨骼系统发育。 位于细胞表面。 以多种结构表达，包括中枢神经系统；早孕;性腺;直觉;和感觉器官。 用于研究 Weissenbacher-Zweymuller 综合征。 该基因的人类直系同源物与结肠癌有关。 与人类 ACVR2A（2A 型激活素 A 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]