ACSL4 - Wikipedia
Long-chain-fatty-acid—CoA ligase 4 is an enzyme that in humans is encoded by the ACSL4 gene. [5] [6] [7] The protein encoded by this gene is an isozyme of the long-chain fatty-acid …
ACSL4 Gene - GeneCards | ACSL4 Protein | ACSL4 Antibody
Dec 24, 2024 · ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) is a Protein Coding gene. Diseases associated with ACSL4 include Intellectual Developmental Disorder, X-Linked …
Science子刊：靶向ACSL4，抑制铁死亡，防治铁死亡相关疾病_澎 …
该研究发现，as-252424是一种特异性和靶向性的acsl4抑制剂，具有显著的抗铁死亡功能，并揭示了其在调控铁死亡中的潜在作用和分子机制，为铁死亡相关疾病的治疗提供了一种潜在治疗方 …
酰基辅酶A合酶ACSL4：铁死亡和脂肪酸代谢的重要靶标,Chinese …
Jul 14, 2023 · 摘要长链酰基辅酶 a (coa) 合酶 4 (acsl4) 是一种将 coa 酯化为特定多不饱和脂肪酸（如花生四烯酸和肾上腺酸）的酶。根据积累的证据，acsl4 催化的花生四烯酰辅酶 a 生物合 …
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid ...
We applied two independent approaches-a genome-wide CRISPR-based genetic screen and microarray analysis of ferroptosis-resistant cell lines-to uncover acyl-CoA synthetase long …
ACSL4 as a Potential Target and Biomarker for Anticancer: From ...
Jul 13, 2022 · Recently, acyl-CoA synthetase long-chain family 4 (ACSL4) is found be participated in the activation of long chain fatty acids metabolism, immune signaling transduction, and …
Cell | 西湖大学揭示癌症转移新靶点：PUFA与铁死亡的“致命组合”
Dec 13, 2024 · acsl4缺失抑制了sk-hep-1-luc细胞的肺转移，但未显著改变体外增殖或皮下肿瘤生长，表明acsl4在肝癌中的促外渗作用具有普遍性。 此外，用ARA处理SK-HEP-1细胞显著增 …
文献解析|ACSL4调控细胞脂质组成，影响铁死亡敏感性
ACSL4. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. 铁死亡是一种由谷胱甘肽过氧化物酶4（GPX4）调控的细胞坏死形式。早期研究揭示了erastin (ERA)通过 …
ACSL4 and polyunsaturated lipids support metastatic …
Jan 23, 2025 · Notably, a UFA metabolism gene, ACSL4, displayed as a top hit among the lung-metastasis-specific mediators (Figure 3 D). ACSL4 catalyzes the conversion of PUFAs …
【Cell】长链酯酰辅酶A合成酶ACSL4 携手多不饱和脂质：为癌细 …
nmnat1和acsl4是调控卵巢癌转移的关键基因 通过体内CRISPR筛选，发现NMNAT1、HADHB、PTPRG和ATP6V1H与肝脏和肺转移相关。 其中NMNAT1介导NAD生物合成并参与各种原发 …