Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene. [5] The ACER2/ sphingosine pathway plays an important role in regulating integrin β1 subunit (ITGB1) maturation and cell adhesion mediated by β1 integrins. [6] ^ "Human PubMed Reference:".

Dec 24, 2024 · ACER2 (Alkaline Ceramidase 2) is a Protein Coding gene. Diseases associated with ACER2 include Farber Lipogranulomatosis and Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy. Among its related pathways are Metabolism and Sphingolipid metabolism.

Mar 15, 2017 · In the present study, we have identified ACER2 promoter and also found that ACER2 is a direct transcriptional target gene of p53. Furthermore, we have demonstrated that ACER2 is required for...

Nov 22, 2024 · ACER2-mediated sphingolipid signaling, particularly through the SphK/S1P pathway, influences cancer development by modulating immune responses, inflammation, and the balance between cell survival and death.

Herein we demonstrate that DNA damage increases sphingosine levels in tumor cells by upregulating alkaline ceramidase 2 (ACER2) and that the upregulation of the ACER2/sphingosine pathway induces PCD in response to DNA damage by increasing the production of reactive oxygen species (ROS).

Herein we report that alkaline ceramidase 2 (ACER2) plays a key role in sustaining the integrity of the placental vasculature by regulating the homeostasis of sphingolipids in mice. The mouse alkaline ceramidase 2 gene (Acer2) is highly expressed in the placenta between embryonic day (E) 9.5 and E12.5.

Title: Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation. Results suggest that the ACER2/sphingosine pathway mediates programmed cell death in response to DNA damage through ROS production.

Human alkaline ceramidase 2 (ACER2) plays an important role in cellular responses by regulating the hydrolysis of ceramides in cells. Here we report its biochemical characterization, membrane topology, and activity regulation.

Dec 11, 2017 · Herein we demonstrate that human alkaline ceramidase 2 (ACER2) is a novel transcriptional target of p53 and that its transactivation by p53 mediates the DDR. We found that p53 overexpression...

ACER2 is a critical sphingolipid metabolizing enzyme, and has been shown to be remarkably up-regulated following various stimuli such as DNA damage. However, the transcriptional regulatory mechanism of ACER2 gene and its potential role in the regulation of autophagy remain unknown.

Herein we report that alkaline ceramidase 2 (ACER2) plays a key role in sustaining the integrity of the placental vasculature by regulating the homeostasis of sphingolipids in mice. The mouse alkaline ceramidase 2 gene (Acer2) is highly expressed in the placenta between embryonic day (E) 9.5 and E12.5.

Feb 8, 2025 · Depletion of the essential autophagy gene ATG5 revealed that ACER2-induced autophagy facilitates its effect on apoptosis. Results suggest that the ACER2/sphingosine pathway mediates programmed cell death in response to DNA damage through ROS production.

Feb 8, 2025 · Using genome-wide association analyses, we identified eight gene-containing loci, including a locus containing Acer2, which encodes a ceramidase and is specifically expressed in the collecting duct. Knockout of Acer2 led to increased susceptibility for lithium-induced diabetes insipidus development.

In this study we explore the role of ACER2, ACER3, and their homologue, the human alkaline ceramidase 1 (ACER1) in mediating the 4-HPR-induced generation of DHS and the cytotoxicity of 4-HPR in tumor cells.

Human alkaline ceramidase 2 (ACER2), a key enzyme that regulates hydrolysis of cellular ceramides, affects cancer cell survival, however its role in HCC has not been well characterized. Our results showed that ACER2 is overexpressed in HCC tissues and cell lines.

Apr 1, 2011 · Here we report that the human alkaline ceramidase 2 (ACER2), which catalyzes the generation of the S1P precursor sphingosine, plays important roles in tumor angiogenesis and growth by controlling S1P release from both endothelial cells and tumor cells.

Mar 15, 2017 · ACER2 is a critical sphingolipid metabolizing enzyme, and has been shown to be remarkably up-regulated following various stimuli such as DNA damage. However, the transcriptional regulatory mechanism of ACER2 gene and its potential role in the regulation of autophagy remain unknown.

Feb 1, 2021 · Here we discuss the discovery of the ACER family, the biochemical properties, structures, and catalytic mechanisms of its members, and its role in regulating sphingolipid metabolism and biological processes in yeast, insects, plants, and mammals. 1. Introduction.

Mar 1, 2023 · Alkaline ceramidase 2 (ACER2) was a sphingolipid metabolizing enzyme localized to the Golgi complex, which could convert ceramide to sphingosine in vivo ( Sun et al., 2010 ). ACER2 was highly expressed in a majority of human tumor tissues ( …

Jan 25, 2024 · Clinical resource with information about ACER2, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.