Wilson disease protein (WND), also known as ATP7B protein, is a copper-transporting P-type ATPase which is encoded by the ATP7B gene. The ATP7B protein is located in the trans …

2024年12月24日 · ATP7B (ATPase Copper Transporting Beta) is a Protein Coding gene. Diseases associated with ATP7B include Wilson Disease and Wolff Syndrome. Among its …

The ATP7B gene provides instructions for making a protein called copper-transporting ATPase 2. This protein is part of the P-type ATPase family, a group of proteins that transport metals into …

2025年2月8日 · The ATP7B gene codes the ATP7B protein, which is an acronym for: ATPase activity, 7 distinct domain, and B class for second P-type ATPase copper binding pump. …

Wilson disease (WD), a Mendelian disorder of copper metabolism caused by mutations in the ATP7B gene, manifests a large spectrum of phenotypic variability. This phenomenon of …

2023年12月20日 · The Atp7b gene is a gene that codes for a protein called copper-transporting ATPase 2 (ATP7B). This protein is responsible for the transport of copper ions across cell …

2025年2月9日 · Title: Integrative analysis of the cuproptosis-related gene ATP7B in the prognosis and immune infiltration of IDH1 wild-type glioma. AP-1gamma2 is an adaptor protein 1 variant …

In ATP7B, the N-terminal sixth metal-binding domain (MBD6) binds at the cytosolic copper entry site of the transmembrane domain (TMD), facilitating the delivery of copper from the MBD6 to …

The N-terminal part (~ 600 residues) of the multi-domain 1400-residue ATP7B constitutes six metal binding domains (MBDs), each of which can bind a copper ion, interact with other …

Two ATP-driven Cu transporters, ATP7A and ATP7B, play essential roles in balancing Cu levels in the brain. Inactivating mutations in either ATP7A or ATP7B are associated with severe …