Achaete-scute homolog 1 is a protein that in humans is encoded by the ASCL1 gene. [5][6] Because it was discovered subsequent to studies on its homolog in Drosophila, the Achaete-scute complex, it was originally named MASH-1 for mammalian achaete scute homolog-1. [7]

2024年12月24日 · ASCL1 (Achaete-Scute Family BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with ASCL1 include Haddad Syndrome and Congenital Central Hypoventilation Syndrome. Among its related pathways are Signaling by NTRKs and Nuclear Events (kinase and transcription factor activation).

2022年4月27日 · ASCL1 acts as a driver of the lineage plastic, neuronal transcriptional program to support treatment resistance and neuroendocrine phenotype. Targeting ASCL1 switches the neuroendocrine...

2025年2月8日 · Ascl1 modulates multiple steps of oligodendrocyte precursor cell development in the postnatal brain and in response to demyelinating insults. Ascl1 directly regulates expression of matrix metalloproteinase-7 and O(6)-methylguanine-DNA methyltransferase.

2019年5月13日 · We found that Ascl1 and Neurog2 generate neurons by binding to largely different sets of genomic sites when expressed in similar chromatin and cellular contexts. Their divergent binding is due to...

In this study, we focus on ASCL1, a class II basic‐helix–loop–helix (bHLH) transcription factor that forms a heterodimer with class I bHLH E‐proteins (such as E47/TCF3) to activate specific target genes (Kageyama, Ohtsuka, Hatakeyama, & Ohsawa, 2005).

ASCL1, also known as a proneural bHLH transcription factor, is a protein that is expressed in oligodendrocyte progenitor cells (OPCs) during both embryonic and early postnatal stages. It plays a role in promoting the fate of OPCs and preventing the premature expression of negative regulators of OPC production.

2014年10月14日 · We determined that achaete-scute homolog 1 (ASCL1), a transcription factor required for proper development of pulmonary neuroendocrine cells, is essential for the survival of a majority of lung cancers (both SCLC and NSCLC) with neuroendocrine features.

2025年1月4日 · Significance of achaete-scute complex homologue 1 (ASCL1) in pulmonary neuroendocrine carcinomas; RNA sequence analyses using small cell lung cancer cells and Ascl1-induced pulmonary neuroendocrine carcinoma cells.

2 天之前 · Inducible co-expression models of all combinations of ASCL1, NEUROD1, POU2F3, YAP1, and ATOH1 using SCLC cell lines showed that some expression combinations, such as ASCL1 and NEUROD1, exhibited ...