Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin and RING subunit much like SCF.

2006年8月9日 · The anaphase promoting complex/cyclosome (APC/C) is a 1.5-MDa ubiquitin ligase complex that initiates sister-chromatid separation and exit from mitosis by targeting cyclin B and securin...

2017年11月22日 · APC/C-mediated coordination of cell cycle progression is achieved through the temporal and spatial regulation of APC/C activity and substrate specificity. The APC/C becomes activated at the onset of mitosis, and ubiquitinates Nek2A and cyclin A (an S- and M-phase cyclin) at prometaphase.

The anaphase-promoting complex or cyclosome (APC/C) controls sister chromatid segregation and the exit from mitosis by catalysing the ubiquitylation of cyclins and other cell cycle regulatory proteins. This unusually large E3 RING-cullin ubiquitin ligase is …

2014年7月20日 · The anaphase-promoting complex/cyclosome (APC/C) is a large E3 ligase that mediates ubiquitin-dependent proteolysis of cell cycle regulatory proteins to control various events during...

The separation of sister chromatids at anaphase, which is regulated by an E3 ubiquitin ligase called the anaphase-promoting complex/cyclosome (APC/C), is arguably the most important irrevocable event during the cell cycle.

The anaphase promoting complex/ cyclosome (APC/C), is an evolutionarily conserved multi-subunit E3 ubiquitin ligase that is primarily known for its ability to trigger the metaphase to anaphase transition during mitosis.

2006年6月15日 · The major ubiquitin ligase required for mitosis is the anaphase-promoting complex/cyclosome (APC/C). This unusually complex E3 ubiquitin ligase targets cell-cycle-related proteins such as cyclins and securin for degradation by the proteasome in mitosis and meiosis.

2016年7月13日 · Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets different substrates for ubiquitylation and therefore regulates a variety of cellular processes such as cell division, differentiation, genome stability, energy metabolism, cell death, autophagy as well as carcinogenesis.

Anaphase-promoting complex / cyclosome (APC/C) is a central gatekeeper of the cell cycle. Although its name suggests that it promotes “anaphase” - a specific step in the cell cycle - APC/C is a large protein complex that monitors many stages of the cell cycle.