Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene. [ 5 ] Annexin 2 is involved in diverse cellular processes such as cell motility (especially that of the epithelial cells ), linkage of membrane-associated protein complexes to the actin cytoskeleton , endocytosis , fibrinolysis, ion channel formation ...

2024年12月24日 · ANXA2 (Annexin A2) is a Protein Coding gene. Diseases associated with ANXA2 include Antiphospholipid Syndrome and Acute Promyelocytic Leukemia. Among its related pathways are Interleukin-12 family signaling and Response of endothelial cells to shear stress.

2019年5月1日 · ANX A2 is an important member of annexin family of proteins expressed on surface of endothelial cells (ECs), macrophages, mononuclear cells and various types of cancer cells. It exhibits high affinity binding for calcium (Ca ++ ) and phospholipids.

2024年2月21日 · Here, we describe the role of annexins as Ca 2+ -regulated membrane binding modules that sense and respond to cellular stress and share our view on future research directions in the field.

Annexin A2 (ANXA2) is a calcium regulated phospholipid-binding protein. It is expressed in some tumor cells, endothelial cells, macrophages, and mononuclear cells, affecting cell survival and mediating interactions between intercellular and ...

Our study revealed that ANXA2 is a biomarker closely related to the malignant phenotype and poor prognosis of glioma, and plays an important role in immune response, inflammatory activity and immunosuppression.

Annexins are a family of calcium- and phospholipid-binding proteins found in nearly all eukaryotes. They are structurally highly conserved and have been implicated in a wide range of cellular activities. In this paper, we focus on Annexin A2 (AnxA2).

2025年2月9日 · Annexin A2 (ANXA2) regulates the transcription and alternative splicing of inflammatory genes in renal tubular epithelial cells. The prognostic significance of annexin A family in glioblastoma. Identification of ANXA2 on epithelial cells as a new receptor for secretory IgA using immunoprecipitation and mass spectrometry.

2016年12月16日 · Title: ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells. FGF19 promotes nasopharyngeal carcinoma progression by inducing angiogenesis via …

6 天之前 · ANXA2 is an emerging tumor biomarker that promotes cancer progression and is linked to poor prognosis. In CRC, ANXA2 accumulates in the cell nucleus, disrupting coilin and causing its abnormal localisation to the centromere, leading to chromosomal instability.