Three TGFβ superfamily receptors specific for TGFβ, the TGFβ receptors, can be distinguished by their structural and functional properties. TGFβR1 (ALK5) and TGFβR2 have similar ligand …

The TGFβ type I receptor kinase (ALK5) is an attractive target for intervention in TGFβ signaling due to its druggability as well as its centrality and specificity in the pathway. A number of …

2014年5月25日 · Our findings describe an unexpected role for ALK5-dependent TGF-β signaling as a regulator of the late stages of adult hippocampal neurogenesis, which may have …

5 天之前 · ALK5’s signaling is modulated by interactions with co-receptors and intracellular regulators. Endoglin and betaglycan influence ligand binding and receptor trafficking. …

2019年5月1日 · Activin receptor-like kinase 5 (ALK5), also known as TGF-β type I receptor (TβRI), plays a key role in the canonical TGF-β signaling pathway.

Our findings describe an unexpected role for ALK5-dependent TGF-β signaling as a regulator of the late stages of adult hippocampal neurogenesis, which may have implications for changes …

Using tamoxifen-inducible Cre-ER™ -mediated ALK5-deficient primary calvarial cell cultures, we found that TGF-β signaling promoted osteoprogenitor proliferation, early differentiation, and …

Inhibition of ALK5 or ALK1 signaling affects TGF-β-mediated podosome induction. Both TRI ALK5 and ALK1 are expressed in BAE cells . To explore their respective roles in podosome …

ALK1 and ALK5 are important factors for the chondrogenic differentiation of BMSCs induced by TGF-β. In addition, ALK1 and ALK5 mediate signal transduction in BMSCs ( 105 , 106 ). BMP …

2019年5月1日 · Our results suggested that the ALK5 signaling pathway plays a critical role in mediating neural plasticity and neurological function recovery via Gadd45b after cerebral …