
TGF beta receptor - Wikipedia
Three TGFβ superfamily receptors specific for TGFβ, the TGFβ receptors, can be distinguished by their structural and functional properties. TGFβR1 (ALK5) and TGFβR2 have similar ligand-binding affinities and can be distinguished from each other only by peptide mapping.
Tgf-beta type I receptor (Alk5) kinase inhibitors in oncology
The TGFβ type I receptor kinase (ALK5) is an attractive target for intervention in TGFβ signaling due to its druggability as well as its centrality and specificity in the pathway. A number of potent, selective ALK5 inhibitors have been discovered which interact with the ATP-binding site of ALK5.
ALK5-dependent TGF-β signaling is a major determinant of late …
2014年5月25日 · Our findings describe an unexpected role for ALK5-dependent TGF-β signaling as a regulator of the late stages of adult hippocampal neurogenesis, which may have implications for changes in...
ALK5: Structural Roles and TGF-β Signaling in Neurodevelopment
5 天之前 · ALK5’s signaling is modulated by interactions with co-receptors and intracellular regulators. Endoglin and betaglycan influence ligand binding and receptor trafficking. Endoglin, highly expressed in endothelial cells and certain neural populations, enhances ALK5’s affinity for TGF-β1 and TGF-β3, promoting sustained Smad2/3 activation.
ALK5 signaling pathway mediates neurogenesis and functional recovery ...
2019年5月1日 · Activin receptor-like kinase 5 (ALK5), also known as TGF-β type I receptor (TβRI), plays a key role in the canonical TGF-β signaling pathway.
ALK5-dependent TGF-β signaling is a major determinant of late …
Our findings describe an unexpected role for ALK5-dependent TGF-β signaling as a regulator of the late stages of adult hippocampal neurogenesis, which may have implications for changes in neurogenesis during aging and disease.
Critical roles of the TGF-β type I receptor ALK5 in perichondrial ...
Using tamoxifen-inducible Cre-ER™ -mediated ALK5-deficient primary calvarial cell cultures, we found that TGF-β signaling promoted osteoprogenitor proliferation, early differentiation, and commitment to the osteoblastic lineage through the selective MAPKs and Smad2/3 pathways.
ALK5 and ALK1 Play Antagonistic Roles in Transforming Growth …
Inhibition of ALK5 or ALK1 signaling affects TGF-β-mediated podosome induction. Both TRI ALK5 and ALK1 are expressed in BAE cells . To explore their respective roles in podosome formation, we first examined the outcome of their stimulation by their ligands.
Perspectives of small molecule inhibitors of activin receptor …
ALK1 and ALK5 are important factors for the chondrogenic differentiation of BMSCs induced by TGF-β. In addition, ALK1 and ALK5 mediate signal transduction in BMSCs ( 105 , 106 ). BMP signaling is also a critical mediator of cartilage differentiation and endochondral ossification.
ALK5 signaling pathway mediates neurogenesis and functional recovery ...
2019年5月1日 · Our results suggested that the ALK5 signaling pathway plays a critical role in mediating neural plasticity and neurological function recovery via Gadd45b after cerebral ischemia, representing a new potential target for cerebral I/R injury.
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