Three TGFβ superfamily receptors specific for TGFβ, the TGFβ receptors, can be distinguished by their structural and functional properties. TGFβR1 (ALK5) and TGFβR2 have similar ligand-binding affinities and can be distinguished from each other only by peptide mapping.

The TGFβ type I receptor kinase (ALK5) is an attractive target for intervention in TGFβ signaling due to its druggability as well as its centrality and specificity in the pathway. A number of potent, selective ALK5 inhibitors have been discovered which interact with the ATP-binding site of ALK5.

2014年5月25日 · Our findings describe an unexpected role for ALK5-dependent TGF-β signaling as a regulator of the late stages of adult hippocampal neurogenesis, which may have implications for changes in...

5 天之前 · ALK5’s signaling is modulated by interactions with co-receptors and intracellular regulators. Endoglin and betaglycan influence ligand binding and receptor trafficking. Endoglin, highly expressed in endothelial cells and certain neural populations, enhances ALK5’s affinity for TGF-β1 and TGF-β3, promoting sustained Smad2/3 activation.

2019年5月1日 · Activin receptor-like kinase 5 (ALK5), also known as TGF-β type I receptor (TβRI), plays a key role in the canonical TGF-β signaling pathway.

Our findings describe an unexpected role for ALK5-dependent TGF-β signaling as a regulator of the late stages of adult hippocampal neurogenesis, which may have implications for changes in neurogenesis during aging and disease.

Using tamoxifen-inducible Cre-ER™ -mediated ALK5-deficient primary calvarial cell cultures, we found that TGF-β signaling promoted osteoprogenitor proliferation, early differentiation, and commitment to the osteoblastic lineage through the selective MAPKs and Smad2/3 pathways.

Inhibition of ALK5 or ALK1 signaling affects TGF-β-mediated podosome induction. Both TRI ALK5 and ALK1 are expressed in BAE cells . To explore their respective roles in podosome formation, we first examined the outcome of their stimulation by their ligands.

ALK1 and ALK5 are important factors for the chondrogenic differentiation of BMSCs induced by TGF-β. In addition, ALK1 and ALK5 mediate signal transduction in BMSCs ( 105 , 106 ). BMP signaling is also a critical mediator of cartilage differentiation and endochondral ossification.

2019年5月1日 · Our results suggested that the ALK5 signaling pathway plays a critical role in mediating neural plasticity and neurological function recovery via Gadd45b after cerebral ischemia, representing a new potential target for cerebral I/R injury.