活化素受体样激酶1（activin receptor-like kinase-1，ACVRL1/ALK1）属于TGF-β家族的I型受体（TβRI或ALK）成员之一，是丝氨酸/苏氨酸激酶受体。 ACVRL1/ALK1基因定位于12q13，含10个外显子，基因组全长约15 kb，编码ACVRL1受体蛋白。 ACVRL1是一种整合在细胞膜上的同形二聚体跨膜糖蛋白，含503个氨基酸残基，由N端胞外区、跨膜区和几乎全由丝氨酸-苏氨酸激酶区构成的胞内区三部分组成。 ACVRL1与其他I型受体在丝氨酸-苏氨酸激酶亚结构域、GS结构 …

ACVRL1 is a receptor in the TGF beta signaling pathway. It is also known as activin receptor-like kinase 1, or ALK1. This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands.

2020年4月1日 · Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in...

In this review, we present an updated view of the mechanism of ALK1 signaling, put forth a unified hypothesis to explain the cellular missteps that lead to AVMs associated with ALK1 deficiency, and discuss emerging roles for ALK1 signaling in diseases beyond HHT.

2024年12月24日 · ALK (ALK Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ALK include Neuroblastoma 3 and Neuroblastoma. Among its related pathways are ASP-3026-resistant ALK mutants and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity.

ALK-1, also known as ACVRL1, is a type I receptor for TGF-β superfamily with 2 ligands, BMP9 and BMP10. ALK-1 is predominantly expressed in endothelial cells and plays a critical role in regulating angiogenesis. ALK-1 is able to bind to TGF-β1 or activins in the presence of either TβR-II or activin type II receptors, respectively.

2011年6月30日 · Activin receptor-like kinase 1 (ALK1) is an EC-restricted receptor of the large TGF-β family. 1 Herein, we will review our current understanding of ALK1 signaling and the potential of ALK1 to serve as a drug target for antiangiogenic therapy for cancer.

2016年11月21日 · ALK1 binds LDL with lower affinity than LDLR and saturates only at hypercholesterolemic concentrations. ALK1 mediates uptake of LDL into endothelial cells via an unusual endocytic pathway that...

2023年6月2日 · Genetic deletion of, or selective monoclonal antibody binding to, activin receptor-like kinase 1 (ALK1) inhibits LDL transcytosis into the endothelium and prevents the development of...

Activin receptor-like kinase-1 (ALK1) induces Smad1/5 phosphorylation, leading to an increase in endothelial cell proliferation and migration, while ALK5 promotes Smad2/3 activation and inhibits both processes.