Allograft inflammatory factor 1 (AIF-1) also known as ionized calcium-binding adapter molecule 1 (IBA1) is a protein that in humans is encoded by the AIF1 gene. [5][6] The AIF1 gene is located within a segment of the major histocompatibility complex class III region.

2024年12月24日 · AIF1 (Allograft Inflammatory Factor 1) is a Protein Coding gene. Diseases associated with AIF1 include Nonarteritic Anterior Ischemic Optic Neuropathy and Traumatic Brain Injury. Among its related pathways are Acute viral myocarditis and Spinal cord injury.

Iba1是细胞骨架结合蛋白，促进细胞膜运动与RAC激活，并在RAC信号通路及吞噬过程中发挥作用。 Iba1促进血管平滑肌细胞及T淋巴细胞增殖，促进淋巴细胞迁移，在巨噬细胞激活与功能中发挥作用。 Iba1作为 F-肌动蛋白结合蛋白，在重塑肌动蛋白细胞骨架中也发挥一定作用。 参与活化小胶质细胞/巨噬细胞状态相关的形态变化，被广泛用作大脑和其他组织中的小胶质细胞/巨噬细胞的标记物。 在小胶质细胞、T淋巴细胞及外周血单核细胞中表达。 Iba1主要定位于细胞膜和细胞 …

Allograft inflammatory factor 1 (AIF1) is a calcium-binding protein that participates in intracellular processes such as phagocytosis, membrane ruffling and F-actin remodeling. Due to its multiple functions, AIF1 is linked with the activation of ...

2025年3月1日 · AIF-1 induces VSMCs to dedifferentiate into macrophage-like cells, enhancing lipid uptake and inflammatory factor secretion through the PKC/NF-κB pathway. Inhibiting AIF-1 could potentially reduce foam cell formation and offer a therapeutic strategy for atherosclerosis.

The allograft inflammatory factor-1 (AIF-1) is a 17 kDa interferon-gamma (IFN-gamma) inducible Ca (2+)-binding EF-hand protein that is encoded within the HLA class III genomic region. Three proteins including ionized Ca (2+)-binding adaptor 1, microglia response factor-1, and daintain are identical with AIF-1.

同种异体移植炎症因子1 (allograft inflammatory factor 1，AIF 1)是从慢性排斥的心脏移植物中克隆的一种高度保守的炎症反应支架蛋白,通过调节细胞因子、趋化因子和诱导型一氧化氮合酶等炎症介质的表达参与炎症反应，是巨噬细胞活化的标志物。 AIF 1具有广泛的生物学特性，参与移植排斥反应、自身免疫性疾病、肿瘤、血管病变、生殖系统疾病和中枢神经疾病的发生及发展，在多种疾病中起重要作用。 关键词: 同种异体移植炎症因子1, 炎症, 移植排斥, 自身免疫, 血管病变. …

该基因编码一种结合肌动蛋白和钙的蛋白质。 该基因由细胞因子和干扰素诱导，可促进巨噬细胞活化和血管平滑肌细胞和 T 淋巴细胞的生长。 该基因的多态性可能与系统性硬化症有关。 可变剪接导致多个转录本变体，但其中一些变体的全长和编码性质尚不确定。 [RefSeq 提供，2016 年 1 月] This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle …

aif-1,同种异体移植物炎症因子,是由143个氨基酸组成的含有一个ef螺旋结构的细胞质的钙结合蛋白,相对分子质量为17 000,它编码在hla-Ⅲ基因的6号染色体上.aif-1从大鼠和人的发生慢性移植排斥反应的同种异体心脏移植物的动脉粥样硬化病变中克隆出来,后从人的同种 ...

AIF-1 boosts the expression of inflammatory mediators such as cytokines, chemokines, inducible nitric oxide synthase (iNOS) and promotes inflammatory cell proliferation and migration. Here we provide an overview of the different pathological processes regulated by AIF-1 mainly including allograft rejection, autoimmune diseases, central nervous ...