The beta-2 adrenergic receptor (β 2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that binds epinephrine (adrenaline), a hormone and neurotransmitter whose signaling, via adenylate cyclase stimulation through trimeric G s proteins, increases cAMP, and, via downstream L-type calcium channel ...

2024年12月24日 · ADRB2 (Adrenoceptor Beta 2) is a Protein Coding gene. Diseases associated with ADRB2 include Asthma and Nocturnal Asthma. Among its related pathways are Activation of cAMP-Dependent PKA and Class A/1 (Rhodopsin-like receptors). Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and enzyme binding.

ADRB2 consists of a single exon of 2015 nucleotides, which encodes a 413 amino acid protein. This review highlights the genetic polymorphisms in ADRB2 and the pivotal role of beta2- AR in the regulation of the cardiac, pulmonary, vascular, endocrine, and central nervous systems.

The beta-2 adrenergic receptor (ADRB2) is an important target for epinephrine, a neurotransmitter in pain signalling. ADRB2 haplotypes affect receptor expression and ligand response, and have been linked to painful non-GI disorders.

2024年11月27日 · This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca (V)1.2.

The Beta-2 Adrenergic Receptor is a type of receptor that undergoes desensitization and downregulation processes after binding with an agonist, leading to uncoupling from G-proteins and internalization pathways. You might find these chapters and articles relevant to this topic.

2020年1月17日 · The ADRB2 gene, located on chromosome 5q31-q32 and encoding for the β-2 AR with 413 amino acids, has more than 80 SNPs identified within its coding region. The mutation that results in the amino acid change at codon 16, where neutral glycine is substituted for basic arginine, is located within the N-terminus of the β-2 AR.

Gene ID: 154, updated on 8-Feb-2025. This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca (V)1.2.

2025年1月4日 · Title: The association of gene polymorphisms in catechol-O'methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) with temporomandibular joint disorders. Association between the Ile164 beta2 Adrenergic Receptor Polymorphism and Fatigue in Patients with Rheumatoid Arthritis.

The β2 adrenergic receptor (ADRB2) is a G protein-coupled transmembrane receptor located on airway smooth muscle cells. ADRB2 activation causes smooth muscular relaxation in response to endogenous catecholamines. ADRB2 is an important regulator of airway smooth muscle tone.