2024年12月24日 · ADRA2A (Adrenoceptor Alpha 2A) is a Protein Coding gene. Diseases associated with ADRA2A include Lipodystrophy, Familial Partial, Type 8 and Lipodystrophy, Congenital Generalized, Type 1. Among its related pathways are Monoamine GPCRs and GPCR downstream signalling.

2017年7月14日 · What is ADRA2A? ADRA2A encodes the α-2A adrenergic receptor, which is a norepinephrine receptor.

2025年2月8日 · ADRA2A and IRX1 are putative risk genes for Raynaud's phenomenon. The alpha-2A-adrenergic receptor gene polymorphism modulates gray matter structural networks, visual memory, and inhibitory cognitive control in children with …

2024年8月4日 · The ADRA2A gene has emerged as a key player in our understanding of ADHD, offering valuable insights into the genetic architecture of attention disorders. Its role in regulating norepinephrine signaling and influencing cognitive processes places it at the heart of ADHD pathophysiology.

The genetic polymorphisms of the alpha-2A adrenergic receptor (ADRA2A), which plays a significant role in sedation, anxiety relief, and antinociception, particularly in dexmedetomidine, may differ in the degree of sedation.

2025年2月8日 · Title: ADRA2A and IRX1 are putative risk genes for Raynaud's phenomenon. The alpha-2A-adrenergic receptor gene polymorphism modulates gray matter structural networks, visual memory, and inhibitory cognitive control in children with …

2009年11月19日 · The culprit gene, ADRA2A, encodes the alpha2A adrenergic receptor and is potentially a valuable lead for diabetes therapy because it can be targeted pharmacologically.

2021年12月20日 · ADRA2A mRNA expression was selectively upregulated in AP-treated schizophrenia subjects (+93%) whereas ADRA2C mRNA expression was upregulated in all schizophrenia subjects (+53%) regardless of...

We describe novel variants and the haplotype structure of the ADRA2A gene. Common genetic ADRA2A variants are not important determinants of baseline cardiovascular measures (plasma norepinephrine, heart rate, and blood pressure) in healthy volunteers.

The ADRA2A gene encodes the main presynaptic inhibitory feedback G protein-coupled receptor regulating norepinephrine release. Activation of ADRA2A inhibits cAMP production and reduces lipolysis in adipocytes (summary by Garg et al., 2016).