Jan 4, 2023 · On July 20, 2022, Nature published three papers on ADAR1 regulating abnormal immune activation through the canonical A-to-I RNA editing pathway. 1, 2, 3 The study by Nicholas et al. demonstrated...

Feb 10, 2025 · In this study, we demonstrate that highly expressed ADAR1 is a crucial oncogenic target in PCa and develop an effective small-molecule ADAR1 inhibitor, ZYS-1, with marked antitumor efficacy and...

2 days ago · ADAR1 converts adenosine to inosine in double-stranded RNA, a process essential for preventing unwarranted immune responses, yet the molecular basis of this editing had remained unclear. Through ...

Recent studies show that editing-dependent functions of ADAR1 protect dsRNA from dsRNA-sensing molecules and inhibit innate immunity and the interferon-mediated response.

Jul 18, 2024 · Adenosine deaminase acting on RNA 1 (ADAR1) converts adenosine to inosine in double-stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 deficiency in humans and mice results in profound inflammatory diseases characterised by the spontaneous induction of innate immunity. In cells lacking ADAR1, unedited RNAs activate RNA ...

2 days ago · ADAR1 converts adenosine to inosine in double-stranded RNA, a process essential for preventing unwarranted immune responses, yet the molecular basis of this editing had remained unclear. Through detailed biochemical profiling and structural analysis, researchers found that ADAR1’s editing activity depends on RNA sequence, duplex length and ...

3 days ago · Deng et al. reveal mechanisms of ADAR1-mediated RNA editing through biochemical profiling and cryo-EM structure determination. They show how disease-related mutations disrupt short RNA editing and highlight key RNA-binding domains, providing insights into immune regulation by ADAR1 and rational targeting of ADAR1 for therapeutic applications.

ADAR1 regulates RNA-induced immune responses by converting adenosine to inosine in double-stranded RNA. Mutations in ADAR1 are associated with human autoimmune disease, and targeting ADAR1 has been proposed for cancer immunotherapy. However, the molecular mechanisms underlying ADAR1-mediated editing …

1 day ago · ADAR1's RNA editing mechanism. Researchers used biochemical and RNA sequencing analyses to explore how disease-associated mutations affect ADAR1's function, demonstrating that specific mutations ...

Mar 12, 2021 · ADAR1p110 edits the A-C mismatches within RNA:DNA hybrids formed between canonical and non-canonical variant repeats. Editing of A-C mismatches to I:C matched pairs facilitates resolution of...