Dec 24, 2024 · ADAMTS5 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5) is a Protein Coding gene. Diseases associated with ADAMTS5 include Osteoarthritis and Bone Deterioration Disease. Among its related pathways are O-linked glycosylation of mucins and Endochondral ossification with skeletal dysplasias.

Aug 9, 2021 · As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. We here provide an updated insight on the regulation of ADAMTS5 and newly discovered therapeutic strategies for OA.

May 30, 2015 · In particular, ADAMTS4 and 5 have emerged as therapeutic targets in arthritis. Multiple ADAMTSs from different sub-groupings exert either positive or negative effects on tumorigenesis and metastasis, with both metalloproteinase-dependent and -independent actions known to occur.

Adamts5-/-mice clearly show increased weight loss and higher viral titres throughout the course of influenza virus infection along with impaired CD8 + T cell migration and immunity. Results Phenotyping of Adamts5-/-Immune Cells. ADAMTS enzymes are widely distributed in human adult tissues and play a key role in normal cellular function.

Domain mapping and mechanistic studies revealed that ADAMTS5 inhibits B16 tumorigenesis through its TSR1 by suppressing tumor angiogenesis, likely by down-regulating pro-angiogenic factors such as vascular endothelial growth factor (VEGF), placenta growth factor (PlGF), and platelet-derived endothelial growth factor (PD-ECGF) in the tumor milieu.

Feb 19, 2025 · ADAMTS5 is downregulated in gastric cancer and suppresses tumor metastasis and angiogenesis; High ADAMTS5 expression is associated with osteoarthritic cartilage deterioration. ADAMTS5 was uniquely downregulated in Barlow's Disease.

The major proteoglycan in the extracellular matrix—aggrecan—is primarily cleaved by the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of genes.1 ADAMTS5 knockout mice have less severe cartilage destruction after induced joint instability compared with wild-type counterparts.2 However, ADAMTS5 regulation ...

Nov 21, 2016 · Although overexpression of ADAMTS5 has been reported in glioblastoma, and head and neck cancer, little has been demonstrated in colorectal cancer types. The present study aimed to clarify the significance of ADAMTS5 for clinicopathological factors and prognosis in colorectal cancer.

May 25, 2017 · To determine whether ADAMTS5 and matrilin 2 levels are altered in calcified aortic valves, we analyzed protein levels of ADAMTS5 and matrilin 2 in normal valve tissues and tissues from noncalcified areas of calcified aortic valves by immunoblotting and immunofluorescence staining.

ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. We here provide an updated insight on the regulation of ADAMTS5 and newly discovered therapeutic strategies for OA.