A disintegrin and metalloproteinase with thrombospondin motifs 5 also known as ADAMTS5 is an enzyme that in humans is encoded by the ADAMTS5 gene. [5][6] ADAMTS5 is a member of …

2024年12月24日 · ADAMTS5 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5) is a Protein Coding gene. Diseases associated with ADAMTS5 include Osteoarthritis and Bone …

ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. We …

Adamts5-/-mice clearly show increased weight loss and higher viral titres throughout the course of influenza virus infection along with impaired CD8 + T cell migration and immunity. Results …

2015年5月30日 · In particular, ADAMTS4 and 5 have emerged as therapeutic targets in arthritis. Multiple ADAMTSs from different sub-groupings exert either positive or negative effects on …

Domain mapping and mechanistic studies revealed that ADAMTS5 inhibits B16 tumorigenesis through its TSR1 by suppressing tumor angiogenesis, likely by down-regulating pro …

ADAMTS5 (Abbaszade et al., 1999; Hurskainen et al., 1999) has a major role in degradation of the cartilage proteoglycan, aggrecan in arthritis (Abbaszade et al., 1999). The most compelling …

2021年11月22日 · Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) as one of the …

2022年1月14日 · As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. Herein, we provide information on …

2021年8月9日 · As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. We here provide an updated insight on …