A disintegrin and metalloprotease 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases, activated by substrate presentation.

A disintegrin and metalloproteinase 17 (ADAM17), also known as tumor necrosis factor-α converting enzyme (TACE), is a membrane-bound enzyme that cleaves cell surface proteins, such as cytokines (e.g. TNFα), cytokine receptors (e.g. IL-6R and TNF-R), ligands of ErbB (e.g. TGFα and amphiregulin) and a …

ADAM17又称TNF-α转化酶（TNF-α converting enzyme，TACE）是一种去整合素-金属蛋白酶（a disintegrin and metalloproteases，ADAMs），通过对膜蛋白进行切割、使胞外片段从细胞膜表面脱落而调控细胞对外界刺激反应，也被称为细胞中的“分子剪刀”。

For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep investigation. Since its discovery as the tumor necrosis factor convertase, it has been considered a major drug target, especially in the context of inflammatory ...

2023年1月12日 · 可溶性tnf-α通过蛋白水解酶adam17，也称为tnf-a转换酶（tace），从跨膜tnf-α（tmtnf-α）裂解，该酶可通过激活tnf-α来协调免疫和炎症反应。鉴于adam17对tnf信号通路的受体和配体的作用，adam17被认为以多种方式影响tnf-α信号传导。

AMAM17是一种参与多种蛋白质胞外域脱落的跨膜金属蛋白酶，具有黏附和蛋白水解特性，它可以使肿瘤坏死因子-α（TNF-α）前体转化为可溶性的TNF-α。 除了剪切TNF-α，该蛋白酶还在许多其他底物的加工中起作用，比如细胞粘附分子、细胞因子、生长因子受体以及表皮生长因子受体（EGFR），在 Notch信号通路 的激活中也起着重要作用。 那么，ADAM17与病毒感染有什么关系呢？ Inoue 和Wang等分别在2007年和2008年提出了SARS-CoV可以通过网格蛋白依赖和非依 …

2024年6月26日 · Our findings reveal a critical post-translational regulation in CD8 + T cells, providing a potential therapeutic strategy of targeting ADAM17 for effective anti-tumor immunity. Upon antigen...

2011年8月1日 · A disintegrin and metalloproteinase 17 (ADAM17), also known as tumor necrosis factor-α converting enzyme (TACE), is a membrane-bound enzyme that cleaves cell surface proteins, such as cytokines (e.g. TNFα), cytokine receptors (e.g. IL-6R and TNF-R), ligands of ErbB (e.g. TGFα and amphiregulin) and adhesion proteins (e.g. L-selectin and ICAM-1).

2022年11月17日 · ADAM17 is a member of the a disintegrin and metalloproteinase (ADAM) family of transmembrane proteases involved in the shedding of some cell membrane proteins and regulating various signaling pathways. More than 90 substrates are regulated by ADAM17, some of which are closely relevant to tumor forma …

2024年3月11日 · ADAM17是一种重要的蛋白酶，属于金属蛋白酶超家族，也被称为TNF-α转化酶，非常关键的参与细胞信号传导的调控。 ADAM17的全称为重组蛋白酶活性域蛋白，其特点在于具有一个包含金属酶活性的结构域。 ADAM17是一种膜结合型的蛋白酶，在活跃的状态下主要位于细胞膜的细胞外表面，可以水解细胞膜上的多种底物蛋白，从而调控细胞活动和信号传导。 目录号 PA1000-9751. ADAM17的基本信息包括分子量约为120kDa，其基因位于人类染色体2q24.3， …