In the human brain, the anterior cingulate cortex (ACC) is the frontal part of the cingulate cortex that resembles a "collar" surrounding the frontal part of the corpus callosum. It consists of Brodmann areas 24, 32, and 33.

Apr 1, 2011 · The anterior cingulate cortex (ACC) lies in a unique position in the brain, with connections to both the “emotional” limbic system and the “cognitive” prefrontal cortex.

Aug 9, 2022 · The anterior cingulate cortex (ACC) is part of the cerebral cortex and envelopes the corpus callosum. The ACC is involved in high-level cognitive functions like decision-making and problem solving, and psychological functions relating …

Jun 7, 2021 · The anterior cingulate cortex (ACC) is a region of the human brain (Brodmann area 24, 33, and 34) located at the cingulate cortex’s most frontal part. The ACC wraps around the corpus callosum, a bundle of nerve fibers found beneath the cerebral cortex, and is located before the posterior cingulate cortex (PCC), which is adjacent to the ...

We review evidence from non-human primate neuroanatomy and structural and functional neuroimaging in humans suggesting that the anterior mid cingulate cortex (aMCC) is an important network hub in the brain that performs the cost/benefit computations necessary for tenacity.

Dec 31, 2009 · The anterior cingulate cortex (ACC) is an integration center that interconnects neurons from the frontal cortex, the thalamus and the amygdala, processing cognitive, emotional and autonomic functions (Shackman et al., 2011; Vogt, 2005). Importantly, the ACC is strongly implicated in the pathophysiology of depression as well as in pain processing.

The anterior cingulate cortex (ACC) is implicated in a broad range of behaviors and cognitive processes, but it has been unclear what contribution, if any, the ACC makes to social behavior. We argue that anatomical and functional evidence suggests ...

Jul 17, 2024 · Here, we tracked ACC activity in male mice performing go/no-go auditory discrimination tasks with manipulated stimulus-reward contingencies. Individual ACC neurons integrate the outcome...

Jul 16, 2018 · Here, we show that the anterior cingulate cortex (ACC) and its input to the basolateral nucleus of amygdala (BLA) contribute to innate fear response to a predator odor in mice. Optogenetic...

Our results provide a whole-brain mapping of efferent projections from the ACC in adult male mice, and these findings are critical for future studies of the molecular and synaptic mechanisms of the ACC and its related network in mouse models of brain diseases.

Anterior cingulate cortex (ACC) is a part of the brain's limbic system. Classically, this region has been related to affect, on the basis of lesion studies in humans and in animals. In the late 1980s, neuroimaging research indicated that ACC was active in many studies of cognition.

May 1, 2020 · The anterior cingulate cortex (ACC), previously known as the precingulate, is a region of the brain surrounding the anterior corpus callosum. It is involved in the limbic system and the prefrontal cortex.

Mar 11, 2025 · The scientists further demonstrated that signals from the ACC to the brain’s periaqueductal gray (PAG) region are crucial for transforming empathy into behavioral responses, like freezing or avoidance. Manipulating this ACC-to-PAG pathway directly affected empathic behaviors, confirming its vital role in translating observed pain into ...

Research examining the functional underpinnings of anterior cingulate cortex (ACC) and its relationship to cognitive control have been described as "perennially controversial" and a "Rorschach Test" for modern neuroscience.

Jan 1, 2021 · Research examining the functional underpinnings of anterior cingulate cortex (ACC) and its relationship to cognitive control have been described as “perennially controversial” and a “Rorschach Test” for modern neuroscience.

As a ubiquitously active brain region , the ACC reflects a multiplicity of functions in both human and animals. Convergent evidence shows the crucial role of the ACC in a functional circuit that mediates pain processing [ 13 , 231 ].

May 9, 2023 · The cingulate gyrus is a part of the brain located in the medial cortex. It is a curved structure that runs from the front to the back of the brain. The cingulate cortex is divided into two parts – the anterior cingulate cortex (ACC) and the posterior cingulate cortex (PCC).

Feb 7, 2024 · In this issue of Neuron, Fetcho, Parekh, et al. 1 show that neurons in the anterior cingulate cortex (ACC) projecting to the nucleus accumbens (NAc) are essential for integrating reward and effort evaluation in mice, and that this circuit is …

This review sheds light on the promising significance of the ACC in orchestrating postnatal and adult neurogenesis in conditions related to memory, cognitive behavior, and associated disorders.

In this paper, I provide a framework for understanding the connectivity and functions of the cingulate cortex, and how the cingulate cortex can be involved in at least three important functions, emotion, action–outcome learning, and memory.