As with other ligand gated ion channels, the 5-HT 3 receptor consists of five subunits arranged around a central ion conducting pore, which is permeable to sodium (Na), potassium (K), and calcium (Ca) ions.

5-HT 3 receptors are ligand-gated ion channels (LGIC) and therefore differ from all other 5-HT (serotonin) receptors whose actions are mediated via G proteins. Their structure and function has placed them in the Cys-loop family of ligand-gated ion channels.

2017年4月25日 · In this study, we show that a serotonin type 3 receptor (5HT3R) agonist induces antidepressant effects as well as hippocampal neurogenesis independent of fluoxetine (a commonly used SSRI).

We concluded that 5-HT1, 5-HT2, 5-HT3, and 5-HT7 receptors in the CNS modulate the pain, but this depends on the distribution of the receptors, dose of agonists or antagonists, administration route, pain type and duration in order to inhibit, excite, or even maintain the nociceptive response.

In this review, the authors look at the structure, function and distribution of 5-HT 3 receptors and how this may influence their role in disease. The authors also describe the existing clinical applications of 5-HT 3 antagonists and the future potential of these drugs.

5-hydroxytryptamine receptor subtype 3 (5-HT 3 R) is a pentameric ligand-gated ion channel (pLGIC) involved in neuronal signaling. It is best known for its prominent role in gut-CNS signaling though there is growing interest in its other functions, particularly in modulating non-serotonergic synaptic activity.

The 5-HT 3 receptor (5-HT 3 R) is a ligand-gated ion channel gated by the neurotransmitter serotonin (5-HT) and belonging to the superfamily of ligand-gated ion channels, a group that includes nicotinic acetylcholine (ACh), GABA, and glycine receptor channels (M …

2024年1月15日 · 5-羟色胺3受体（5-hydroxytryptamine type 3 receptor，5-HT R）是5-羟色胺受体家族中唯一的一类配体门控离子通道，通过对Na 、K 、Ca 等离子的高通透性以及继发性电压门控Ca 离子通道的激活从而诱发神经元兴奋性的快速上调或轴突末梢的神经递质释放。 在中枢神经系统，5-HT R广泛表达于内侧前额叶皮质、杏仁核、海马体和导水管周围灰质等与焦虑反应密 …

Receptor activation either leads to fast excitatory responses or modulation of neurotransmitter release depending on their neuronal localisation. 5-HT (3) receptors are known to be expressed in the central nervous system in regions involved in the vomiting reflex, processing of pain, the reward system, cognition and anxiety control.

2020年12月1日 · 5-hydroxytryptamine receptor subtype 3 (5-HT 3 R) is a pentameric ligand-gated ion channel (pLGIC) involved in neuronal signaling. It is best known for its prominent role in gut-CNS signaling though there is growing interest in its other functions, particularly in modulating non-serotonergic synaptic activity.