5-HT 3 receptors are ligand-gated ion channels (LGIC) and therefore differ from all other 5-HT (serotonin) receptors whose actions are mediated via G proteins. Their structure and function has placed them in the Cys-loop family of ligand-gated ion channels.

5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers) are a class of medicines that are used for the prevention and treatment of nausea and vomiting, particularly that caused by chemotherapy, radiation therapy, or postoperatively. 5-HT3 is an abbreviation for serotonin that may also be written as 5 ...

Apr 19, 2024 · Selective serotonin receptor (5-HT3) antagonists block serotonin, specifically targeting gastrointestinal (GI) vagal nerve terminals and the chemoreceptor trigger zone within the central nervous system.

The receptors involved in the nociceptive pathway are 5-HT1, 5- HT2, 5-HT3 and 5-HT7. 5-HT1 is coupled to the G i/o protein and it reduces levels of cAMP generating anti and pronociceptive effects. 5-HT2 is coupled to the G q/11 protein and its activation leads to an increase of IP3 and DG levels, generating an antinociceptive effect. 5-HT3 is ...

Serotonin (5-HT)3 receptors are the only ligand-gated ion channel of the 5-HT receptors family. They are present both in the peripheral and central nervous system and are localized in several areas involved in mood regulation (e.g., hippocampus or ...

Jan 15, 2024 · 5-羟色胺3受体（5-hydroxytryptamine type 3 receptor，5-HT 3 R）是5-羟色胺受体家族中唯一的一类配体门控离子通道，通过对Na + 、K + 、Ca 2+ 等离子的高通透性以及继发性电压门控Ca 2+ 离子通道的激活从而诱发神经元兴奋性的快速上调或轴突末梢的神经递质释放。

Serotonin type 3 (5-HT(3)) receptors are pentameric ion channels belonging to the superfamily of Cys-loop receptors. Receptor activation either leads to fast excitatory responses or modulation of neurotransmitter release depending on their neuronal localisation. 5-HT(3) receptors are …

The 5-HT 3 receptor is a widely expressed, cation-selective member of the Cys loop receptor family. A range of studies, in particular heterologous expression and molecular modeling, have revealed many molecular details of its distribution, structure, function, and pharmacology.

5-HT 3 receptors are found postsynaptically to serotonergic neurons in the central and peripheral nervous systems. 5-HT 3 receptors initially appeared to be confined to peripheral neurons, where they mediate depolarizing actions of 5-HT and modulate neurotransmitter release.

The 5-HT 3 receptor antagonist alosetron is an effective treatment for irritable bowel syndrome as it decreases gut transit , increases fluid absorption and reduces pain in irritable bowel syndrome patients [63-65].