The application of a murine cancer cell line, such as 4T1, in a mouse model is of great value for preclinical TNBC studies. The 4T1 cell line is widely used as a syngeneic model for human triple-negative breast cancer, which is responsible for more than 17% of breast cancers diagnosed worldwide each year.

4T1 is a 6-thioguanine resistant cell line selected from the 410.4 tumor without mutagen treatment. When injected into BALB/c mice, 4T1 spontaneously produces highly metastatic tumors that can metastasize to the lung, liver, lymph nodes and brain while the primary tumor is …

The 4T1 mammary carcinoma is a transplantable tumor cell line that is highly tumorigenic and invasive and, unlike most tumor models, can spontaneously metastasize from the primary tumor in the mammary gland to multiple distant sites including lymph nodes, blood, liver, lung, brain, and bone The 4T1 …

4T1 is highly tumorigenic, highly invasive and spontaneously metastasized from the primary tumor site. It can be used in orthotopic and flank models for study of primary tumors and for late-stage metastatic disease.

The 4T1 mouse mammary tumor cell line is one of only a few breast cancer models with the capacity to metastasize efficiently to sites affected in human breast cancer. Here we describe two 4T1 cell lines modified to facilitate analysis of tumor ...

The murine mammary carcinoma 4T1 causes a leukemoid reaction with profound granulocytosis coincident with the production of tumour-derived growth factors. Here, we study the evolving cellular landscape of primary tumours and metastatic tumour foci ...

4T1 cells are 6-thioguanine (6-TG)–resistant murine MBC cells derived from a lung metastasis of the 410.4 cell line, itself a fourth transplant generation of a metastatic nodule of the syngeneic 410 tumor cell line in BALB/c mice (28, 29). 4T1 cells generate primary tumors and spontaneously metastasize to multiple distant sites following ...

Sep 4, 2024 · To investigate how E-cadherin regulates metastasis, we examined the highly metastatic, E-cadherin-positive murine 4T1 breast cancer model, together with the less metastatic, 4T1-related cell lines 4T07, 168FARN and 67NR.

The murine mammary cancer cell line 4T1 is one of the most often used model systems for breast cancer and in particular TNBC. Here, we could confirm that 4T1 indeed resembles metastatic TNBC at the transcriptional level with respect to key markers Esr1, Erbb2, and Pgr.

4T1 is a breast tumour cell line originating from a mammary tumour that spontaneously arose in mouse BALB/c strain. These highly invasive and tumorigenic cells closely mimic human breast cancer's behaviour in terms of growth and metastatic spread. Specifically, the 4T1 tumour model investigates triple-negative breast cancer (TNBC).