4T1 is a 6-thioguanine resistant cell line selected from the 410.4 tumor without mutagen treatment. When injected into BALB/c mice, 4T1 spontaneously produces highly metastatic tumors that can metastasize to the lung, liver, lymph nodes and brain while the primary tumor is …

The 4T1 mammary carcinoma is a transplantable tumor cell line that is highly tumorigenic and invasive and, unlike most tumor models, can spontaneously metastasize from the primary tumor in the mammary gland to multiple distant sites including lymph nodes, blood, liver, lung, brain, and bone The 4T1 …

4T1 is a breast tumour cell line originating from a mammary tumour that spontaneously arose in mouse BALB/c strain. These highly invasive and tumorigenic cells closely mimic human breast cancer's behaviour in terms of growth and metastatic spread. Specifically, the 4T1 tumour model investigates triple-negative breast cancer (TNBC).

The 4T1 cell line is considered an animal model for stage IV human breast cancer, as it is able to spontaneously metastasize in both post-operative and non-surgical models (CLS=300300). Doubling time: 12.6 hours (ATCC=CRL-2539).

The well-characterized 4T1 series of cell lines 38 includes five isogenic tumorigenic lines (67NR, 168FARN, 4TO7, 66cl4, and 4T1) that originated from one spontaneous tumor in a BALB/cfC3H mouse. Each cell line displays unique tumorigenic and metastatic capabilities.

The 4T1 murine breast carcinoma orthotropic model is an ideal system for the studying of the molecular, cellular, and pathological basis of breast cancer and metastatic disease, as well as the studying of therapeutic options.

Jul 23, 2020 · The 4T1 murine mammary cancer cell line is one of the most widely used breast cancer models. Here, we present an integrated map of the genome, transcriptome, and immunome of 4T1. Results: We found Trp53 (Tp53) and Pik3g to be mutated.

Sep 4, 2024 · To investigate how E-cadherin regulates metastasis, we examined the highly metastatic, E-cadherin-positive murine 4T1 breast cancer model, together with the less metastatic, 4T1-related cell lines 4T07, 168FARN and 67NR.

4T1 cells are 6-thioguanine (6-TG)–resistant murine MBC cells derived from a lung metastasis of the 410.4 cell line, itself a fourth transplant generation of a metastatic nodule of the syngeneic 410 tumor cell line in BALB/c mice (28, 29). 4T1 cells generate primary tumors and spontaneously metastasize to multiple distant sites following ...

4T1 is highly tumorigenic, highly invasive and spontaneously metastasized from the primary tumor site. It can be used in orthotopic and flank models for study of primary tumors and for late-stage metastatic disease.