2024年9月12日 · The Janus kinase 2 (JAK2) gene directs cells to make the JAK2 protein, which stimulates cell growth and division. Learn what can cause a JAK2 gene mutation and …

2024年12月25日 · JAK2 (Janus Kinase 2) is a Protein Coding gene. Diseases associated with JAK2 include Polycythemia Vera and Thrombocythemia 3. Among its related pathways are …

The JAK2 gene provides instructions for making a protein that promotes the growth and division (proliferation) of cells. This protein is part of a signaling pathway called the JAK/STAT …

JAK2 mutations can act as central drivers of myeloproliferative neoplasia, a pre-leukemic and age-related malignancy. Likewise, hyperactive JAK-signaling is a hallmark of immune …

tyrosine-protein kinase JAK2, JAK-2, Janus kinase 2 (a protein tyrosine kinase) LncRNA BRE-AS1 regulates the JAK2/STAT3-mediated inflammatory activation via the miR-30b-5p/SOC3 …

2025年2月20日 · Fatty Acid Binding Protein-4 Silencing Inhibits Ferroptosis to Alleviate Lipopolysaccharide-induced Injury of Renal Tubular Epithelial Cells by Blocking Janus Kinase …

2025年1月18日 · Mutations in this gene are associated with numerous inflammatory diseases and malignancies. This gene is a downstream target of the pleiotropic cytokine IL6 that is produced …

2025年3月14日 · Explore the impact of JAK2 mutations on blood cell regulation, diagnostic strategies, and their relevance in myeloproliferative conditions and ongoing research. ... The …

JAK2 is a member of the Janus kinase (JAKs) family of non-receptor protein tyrosine kinases, which includes JAK1–3 and TYK2.

2023年11月13日 · One of the most commonly mutated proteins found in MPNs is the Janus kinase 2 (JAK2) protein. The discovery of JAK2 changed how doctors diagnose and treat …