2024年12月25日 · IL1RL1 (Interleukin 1 Receptor Like 1) is a Protein Coding gene. Diseases associated with IL1RL1 include Chicken Egg Allergy and Conjunctivitis . Among its related pathways are IL-1 Family Signaling Pathways and Constitutive Signaling by Aberrant PI3K in …

IL1RL1 is a member of the Toll-like receptor superfamily based on the function of its intracellular TIR domain, but its extracellular region is composed of immunoglobulin domains. Unlike other members of the family IL1RL1 does not induce an inflammatory response through activation of NF-κB, although it does activate MAP kinases. [8]

白介素 1 受体样 1： 由该基因编码的蛋白质是白介素 1 受体家族的成员。对小鼠相似基因的研究表明，该受体可被促炎刺激物诱导，并可能参与辅助性 T 细胞的功能。该基因、白细胞介素 1 受体 I 型 (IL1R1) 、白细胞介素 1 受体 II 型 (IL1R2) 和白细胞介素 1 受体样 2 (IL1RL2) 在映射到染色体 2q12 的区域中 ...

IL-1RL1 gene transcript encodes different isoforms generated through alternative splicing. Its soluble isoform, IL-1RL1-a or sST2, acts as a decoy receptor by sequestering IL-33, thereby inhibiting IL1RL1-b/IL-33 signalling.

小鼠 Mouse Il1rl1 靶点分子功能（预测） Enables interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including negative regulation of T-helper 1 type immune response; positive regulation of macrophage activation; and regulation of …

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-epsilon4 in female patients with Alzheimer's disease. Single nucleotide variants in the IL33 and IL1RL1 (ST2) genes are associated with periodontitis and with Aggregatibacter actinomycetemcomitans in the dental plaque biofilm: A putative role in understanding the ...

IL1RL1，即白细胞介素-1受体样1，是Toll样/白细胞介素-1受体家族的一员，其结构包含一个细胞外配体结合域、跨膜域和细胞内信号传导域。 IL1RL1主要参与由IL-33介导的信号通路，通过与IL-33结合触发细胞内信号传导，如NF-κB和MAPK通路的激活，进而在免疫调节和炎症 ...

2025年2月8日 · IL1RL1 encodes a member of the interleukin 1 receptor family. IL1RL1 has been confused in the published literature with ST2 (GeneID: 6761) on chromosome 11 which is a region that represents a putative locus associated with various forms of cancer.

2021年8月9日 · Our results suggest that the IL33-IL1RL1 signalling pathway does not contribute to the genetic network underlying IgAV.

位于质膜外侧和细胞外基质。在几个结构中表达，包括免疫系统；肌肉骨骼系统；唾液腺；皮肤；和视觉系统。这个基因的人类正显子(s)参与哮喘和冠状动脉疾病。与人类il1rl1(白细胞介素1受体类似1)正显子同源。[由基因组资源联盟，2022年4月提供]