The ventromedial prefrontal cortex (vmPFC) is a part of the prefrontal cortex in the mammalian brain. The ventral medial prefrontal is located in the frontal lobe at the bottom of the cerebral hemispheres and is implicated in the processing of risk and fear, as it is critical in the regulation of amygdala activity in humans. [2] .

The ventromedial prefrontal cortex (vmPFC) comprises a set of interconnected regions that integrate information from affective sensory and social cues, long-term memory, and representations of the ‘self’. Though the vmPFC is implicated in a variety of seemingly disparate processes, these processes are organized around a common theme.

Among them, ACC and dorsal region of the PL are also defined as the dorsal component (dmPFC), while the ventral PL, IL, and dorsal peduncular cortex (DPC) belong to a ventral part (vmPFC). These regions have connectional and functional homology to human Brodmann areas.

In this review, we summarize data from a diverse array of human and animal studies demonstrating that vmPFC is a key node of cortical and subcortical networks that subserve at least three broad domains of psychological function linked to psychopathology.

In this review, we summarize data from a diverse array of human and animal studies demonstrating that the vmPFC is a key node of cortical and subcortical networks that subserve at least three broad domains of psychological function linked to psychopathology.

May 27, 2024 · Ventromedial prefrontal cortex (vmPFC) is vital for decision-making. Functional neuroimaging links vmPFC to processing rewards and effort, while parallel work suggests vmPFC involvement in...

Ventromedial prefrontal cortex (vmPFC) is vital for decision-making. Functional neuroimaging links vmPFC to processing rewards and effort, while parallel work suggests vmPFC involvement in prosocial behaviour. However, the necessity of vmPFC for these functions is unknown.

Jul 26, 2011 · One prominent theoretical perspective highlights the top–down inhibition of amygdala by ventromedial prefrontal cortex (vmPFC) as a crucial neural mechanism that may be defective in...

Nov 5, 2008 · Recent progress in neuroscience revealed diverse regions of the CNS which moderate autonomic and affective responses. The ventro-medial prefrontal cortex (vmPFC) plays a key role in these regulations. There is evidence that vmPFC activity is associated with cardiovascular changes during a motor task that are mediated by parasympathetic activity.

Jan 7, 2020 · In particular, ventromedial PFC (vmPFC) is thought to represents the latent structures of experience 4, 5, coding for causal links 6, and task-related cognitive maps 7.