p14arf - Wikipedia
p14ARF (also called ARF tumor suppressor, ARF, p14 ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus). [1] p14ARF is induced in response to …
p14ARF基因 - 百度百科
p14ARF基因（p14ARF gene）是2017年全国科学技术名词审定委员会公布的老年医学名词，出自《老年医学名词》第一版。 肿瘤抑制基因，编码的蛋白能稳定和提高细胞p53水平，具有显著 …
P14ARF: The Absence that Makes the Difference - PMC - PubMed …
P14ARF is a tumor suppressor encoded by the CDKN2a locus that is frequently inactivated in human tumors. P14ARF protein quenches oncogene stimuli by inhibiting cell cycle progression …
p14ARF interacts with the focal adhesion kinase and protects
2017年4月24日 · Here, we present data showing that during cell adhesion and spreading, p14ARF is delocalized from nucleoli to sites of actin polymerization concentrating at focal …
P14arf - an overview | ScienceDirect Topics
p14ARF is a tumor suppressor gene located within the INK4bARF-INK4a locus of 9p21 chromosome. This gene encodes the corresponding 14 kDa p14ARF protein, which is …
Two arginine rich domains in the p14ARF tumour suppressor
2000年6月19日 · The INK4a/ARF locus encodes two distinct tumour suppressors, p16 INK4a and p14ARF, that regulate cell cycle progression via the pRB and p53 pathways, respectively. The …
p14ARF links the tumour suppressors RB and p53 - Nature
1998年9月10日 · Here we show that E2F-1 directly activates expression of the human tumour-suppressor protein p14ARF (the mouse homologue is called p19ARF), which binds to the …
Regulation of the p14ARF-Mdm2-p53 pathway: An overview
2006年10月1日 · P14ARF, P19ARF in the mouse, is a 15-kDa protein that blocks the G1 and G2 phases in the cell cycle and inhibits growth of abnormal cells by indirectly activating p53 (Silva …
P14ARF相关信号通路 - 百度学术
p14ARF是新近发现的一种具有细胞周期调节功能的抑癌基因,P14ARF主要定位于核 仁,但也有少部分位于核质.p14ARF在部分人类肿瘤中频发失活,其表达异常导致肿瘤的发生机制及以P14ARF …
P14ARF: The Absence that Makes the Difference - PubMed
2020年7月20日 · Here, we deepened this new facet of p14 ARF which we believe is relevant to its tumor suppressive role in the cell. To this aim, we generated a monoclonal HCT116 cell line …