mTORC2 controls cell survival and proliferation mainly through phosphorylation of several members of the AGC (PKA/PKG/PKC) protein kinase family. mTORC2 regulates actin cytoskeleton through PKCα [33] but is able to phosphorylate other members of the PKC family that have various regulatory functions in cell migration and cytoskeletal remodeling.

细胞内存在mtorc1和mtorc2两种不同的复合体。 它们接受着不同的调控，也有不同的作用。 mTORC1主要调节着细胞生长和代谢，对雷帕霉素敏感。

2023年1月5日 · While less is known about mTORC2, the availability of acute small molecule inhibitors and multiple genetic models has led to increased understanding about the role of mTORC2 in autophagy. Emerging evidence suggests that the regulation of mTORC2 in autophagy is mainly through its downstream effector proteins, and is variable under different ...

mTORC2 is a negative regulator of macroautophagy and chaperone‐mediated autophagy via its ability to signal to various downstream effectors shown to modulate autophagy in mammals including AKT, PKC, SGK‐1, and FOXO transcription factors.

作者以哺乳动物tor（mtor）为重点，全面性地总结回顾了所有已报道的mtor直接磷酸化底物，并根据近期的结构信息，探讨了mtorc1和mtorc2在具有相同催化亚基的情况下，如何选择和磷酸化不同的底物。

mTOR is a serine/threonine protein kinase in the PI3K-related kinase (PIKK) family that forms the catalytic subunit of two distinct protein complexes, known as mTOR Complex 1 (mTORC1) and 2 (mTORC2) (Figure 1A). mTORC1 is defined by its three core components: mTOR, Raptor (regulatory protein associated with mTOR), and mLST8 (mammalian lethal ...

The mechanistic target of rapamycin (mTOR) plays a central role in cellular growth and metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is known about the regulation and functions of mTORC1 due to availability of a ...

mTORC2 controls glycolysis via Akt-dependent and -independent mechanisms. Akt has long been studied as a central regulator of glucose metabolism. It modulates glycolytic enzymes such as hexokinase and PFK2 as well as the glucose transporter GLUT1 (262, 263).

2022年5月16日 · mTOR is a central growth regulatory kinase whose function has been intensively studied, revealing a bevy of downstream effects, many of which are indirect. Here, Hall and colleagues discern which targets are validated direct substrates of its two complexes, mTORC1 and mTORC2, and propose a target motif.

2022年6月29日 · mtorc2是mtor、mlst8、雷帕霉素不敏感的 mtor 伴侣(rictor) 和哺乳动物应激激活图激酶相互作用蛋白 1 (msin1) 组成的异四聚体二聚体。 mTORC1与mTORC2示意图 mTOR信号通路