Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene. [5] [6] [7]Together with GRM6, GRM7 and GRM8 it belongs to group III of the metabotropic glutamate receptor family. Group III receptors are linked to the inhibition of the cyclic AMP cascade. [7] Activation of GRM4 has potential therapeutic benefits in the treatment of parkinson's disease.

The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic process. They are members of the group C family of G-protein-coupled receptors, or GPCRs. [1] . Like all glutamate receptors, mGluRs bind with glutamate, an amino acid that functions as an excitatory neurotransmitter.

The group III metabotropic glutamate receptors (mGluRs), comprising mGluR4, mGluR6, mGluR7, and mGluR8, offer neuroprotective potential in mitigating excitotoxicity during ischemic brain injury, particularly in neonatal contexts.

Nov 9, 2021 · Recently, mGluR4 has been reported to be expressed on immune cells and have an impact on regulating the immune system. This chapter summarized the works associated with the immunogenic function of mGluR4 and its potential underlying mechanisms.

Dec 25, 2024 · GRM4 (Glutamate Metabotropic Receptor 4) is a Protein Coding gene. Diseases associated with GRM4 include Spinocerebellar Ataxia 18 and Epilepsy, Myoclonic Juvenile. Among its related pathways are GPCR downstream signalling and Sensory perception of taste.

Feb 7, 2019 · Group II metabotropic receptors include mGluR2 and mGluR3, while Group III metabotropic receptors include mGluR4, mGluR6, mGluR7, and mGluR8. Both Group II and Group III receptors share a major sequence homology (~70%), and they normally inhibit glutamatergic neurotransmission (Conn and Pin, 1997).

Mar 21, 2021 · Several studies have shown that glutamate neurotransmission in the nucleus accumbens (NAc) is required for the development of morphine-induced conditional place preference (CPP). In addition, metabotropic glutamate receptors (mGluRs) in NAc play important roles in the reward pathways.

May 2, 2005 · Recently, we reported that mGluR4 mediates 5-fluorouracil resistance in a human colon cancer cell line. In this study, we evaluated the nonneural expression of mGluR4 and clarified the existence of mGluR4 in normal colon epithelium and colorectal carcinomas.

Sep 30, 2024 · In particular, ligands of G protein-coupled receptors (GPCRs), including metabotropic glutamatergic receptors (mGluRs), have been recognized as promising options for inhibiting excessive Glu transmission.

AMPA receptors (GluR1-4) evoke excitatory postsynaptic potentials and mediate fast (< 10 ms) synaptic transmission. In contrast, Kainate receptors (GluR5-6 and KA1-2) and NMDA receptors (NR1-3) mediate slower synaptic transmission (10-100 ms) and exert effects on plasticity.