c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc. In cancer , c-myc is often constitutively (persistently) expressed.

The c-myc gene is a central oncogenic switch for oncogenes and the tumor suppressor APC. The APC tumor suppressor protein mediates the degradation of β-catenin.

Under normal circumstances c-Myc is dependent on mitogenic stimulation for its expression and function. c-Myc is a multifunctional transcription factor which drives the multiple synthetic functions necessary for rapid cell division while at the same time inhibiting expression of genes with antiproliferative functions.

Summary Deregulated expression of c-MYC occurs in a broad range of human cancers and is often associated with poor prognosis, indicating a key role for this oncogene in tumour progression.

2021年9月10日 · The MYC oncogene (also known as c-MYC) is part of a superfamily of genes with products that are among the most commonly activated in human cancers 1,2,3,4.

2024年12月25日 · MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit.Among its related pathways are Prolactin Signaling and Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.Gene Ontology (GO) …

2025年2月19日 · Title: Prognostic Impact of Notch1 Intracellular Domain, P63, and c-MYC in Lacrimal Gland Adenoid Cystic Carcinoma. MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer.

3 天之前 · c-MYC is an oncogenic transcription factor that plays a crucial role in the regulation of downstream targets involved in proliferation, apoptosis, differentiation, metabolism, signaling, and immune response processes whose deregulation leads to the progression of different pathologies. The development of selective and potent small-molecule inhibitors of c-MYC remains a grand …

The MYC gene which consists of 3 paralogs, C-MYC, N-MYC and L-MYC, is one of the most frequently deregulated driver genes in human cancer. Because of its high prevalence of deregulation and its causal role in cancer formation, maintenance and progression, targeting MYC is theoretically an attractive …

The MYC proto-oncogenes encode a family of transcription factors that are among the most commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or upregulation of MYC-related pathways by alternate mechanisms occur in the vast majority of cancers. MYC proteins are master regulat …

c-Myc is a widely acting transcription regulatory factor that plays a regulatory role in various cellular processes such as proliferation, differentiation, and apoptosis. Other family members include v-Myc, n-Myc, and l-Myc. Read our c-Myc target tip to …

We propose that c-Myc is a structural modifier of the genome that affects the nuclear organization and an important molecule in tumor cell progression through the induction of genomic instability.

The MYC oncogene (also known as c-MYC) is part of a superfamily of genes with products that are among the most commonly activated in human cancers 1–4.

2021年3月10日 · The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL, which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc, respectively. Myc protein ...

c-MYC is one of the most essential transcriptional factors, regulating a diverse array of cellular functions, including proliferation, growth, and apoptosis. Dysregulation of c-MYC is essential in the pathogenesis of a number of B-cell lymphomas, ...

2021年1月4日 · c-Myc is a transcription factor that is constitutively and aberrantly expressed in over 70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression in mice with only mild and fully reversible side effects, suggesting this to …

2021年8月25日 · c-MYC controls global gene expression and regulates cell proliferation, cell differentiation, cell cycle, metabolism and apoptosis. According to some estimates, MYC is dysregulated in ≈70% of human cancers and strong evidence implicates aberrantly expressed MYC in both tumor initiation and maintenance.

23 小时之前 · Targeting c-Myc has emerged as a potential therapeutic strategy for TNBC, a highly aggressive and deadly breast cancer form. This review highlights c-Myc as a pharmacological target, discussing antitumor compounds in preclinical and clinical trials.

Reduction of c-myc expression and its inappropriate expression can be associated with cellular apoptosis. This review outlines the nature and regulation of the c-myc gene and of c-Myc and presents the systems and conditions in which Myc-related apoptotic events occur.

2025年2月18日 · Correlation between (C) MYC expression level, (D) Notch signaling activity, or (E) non-NE GSVA score and response to chemotherapy. Survival curves for progression-free survival in patients receiving chemotherapy, grouped by the expression level of gene set (F) MYC_TARGETS_V1, (G) MYC_TARGETS_V2, or (H) MYC_UP_V1_UP.

2001年10月8日 · c-MYC is the prototype for oncogene activation by chromosomal translocation. In contrast to the tightly regulated expression of c-myc in normal cells, c-myc is frequently deregulated in...

c-MYC is overexpressed in several types of malignant tumors including colorectal cancer, and is necessary for the uncontrolled proliferation of cancer cells. Single or combined therapies based on c-MYC targeting are represented by various strategies.

3 天之前 · The viral supernatant was harvested 48 h post-transfection and quantified using the Lenti-XTM qRT–PCR Titration kit (Takara Bio) according to the manufacturer’s instructions. pLenti-C-MYC-DDK ...