ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein normally expressed near the surface membrane of lymphocytes (T cells, natural killer cells, and a subset of B cells). [5] . It is most prominently known to be recruited upon antigen binding to the T cell receptor (TCR), and it plays a critical role in T cell signaling.

蛋白质组学研究发现lck的负反馈调节主要受zap70影响。抑制zap70催化活性导致lck（y394）磷酸化增加，y192磷酸化降低。y192磷酸化导致lck对cd3ζ链的itam磷酸化减少，改变sh2结构域对特定配体的特异性，抑制lck催化活性并减弱下游信号激活。 zap70节点的调节

该基因编码一种属于蛋白酪氨酸激酶家族的酶，它在 T 细胞发育和淋巴细胞活化中发挥作用。 这种酶在 T 细胞抗原受体 (TCR) 刺激后在酪氨酸残基上磷酸化，在 TCR 介导的信号转导的初始步骤中与 Src 家族激酶 Lck 和 Fyn 结合发挥作用。 这种酶对于胸腺细胞的发育也是必不可少的。 该基因的突变会导致选择性 T 细胞缺陷，这是一种严重的联合免疫缺陷病，其特征是选择性缺乏 CD8 阳性 T 细胞。 已为该基因发现了编码不同亚型的两种转录物变体。 [RefSeq 提供，2008 年 7 月]

Dec 25, 2024 · ZAP70 (Zeta Chain Of T Cell Receptor Associated Protein Kinase 70) is a Protein Coding gene. Diseases associated with ZAP70 include Immunodeficiency 48 and Autoimmune Disease, Multisystem, Infantile-Onset, 2. Among its related pathways are Immune response NFAT in immune response and TCR Signaling (Qiagen).

ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease.

Nov 15, 2019 · Zeta-chain-associated protein kinase 70（ZAP70）是在 T 细胞信号转导过程中具有关键作用的胞质酪氨酸蛋白激酶，当 T 细胞接触到激活信号时，CD3ζ ITAM 发生磷酸化并与 ZAP70 蛋白的 SH2 结构域结合，使得 ZAP70 蛋白发生磷酸化作用并激活下游级联反应。

ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease.

Aug 31, 2022 · In an elegant study using in-depth time-resolved analyses of the total TCR-stimulated phosphoproteome and protein–protein interactions in CD8 + T cells, the authors identify full activation of the...

Oct 20, 2009 · ZAP70-related combined immunodeficiency (ZAP70-related CID) is a cell-mediated immunodeficiency caused by abnormal T-cell receptor (TCR) signaling. Affected children usually present in the first year of life with recurrent bacterial, viral, and opportunistic infections, diarrhea, and failure to thrive.

In this review, we will discuss the role of ZAP70 in T cell activation and focus on what we learnt from pathological conditions associated with defective expression or activity of the ZAP70 kinase.