ZT-1 is a pro-drug that is rapidly absorbed and converted into huperzine A, and ZT-1 is well tolerated in healthy Chinese volunteers.

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2013年12月11日 · The Swiss company Debiopharm tested a synthetic huperzine derivative and prodrug, ZT-1, aka DEBIO 9902. It was reported to be well-tolerated, rapidly absorbed, and converted into huperzine A, in a small Phase 1 trial in healthy Chinese volunteers ( Jia et …

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2013年7月5日 · In this study, we assessed the pharmacokinetics and tolerance to single and multiple doses of ZT-1 in healthy volunteers. Plasma and urine concentrations of ZT-1 were determined by LC-MS/MS, and pharmacokinetic parameters …

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