Tight junction protein ZO-1 also known as Zonula Occludens-1 (ZO-1), is a 220-kD peripheral membrane protein that is encoded by the TJP1 gene in humans. [5] It belongs to the family of zonula occludens proteins (ZO-1, ZO-2, and ZO-3), which are tight junction-associated proteins and of which, ZO-1 is the first

2024年9月21日 · ZO-1，全称为zonula occludens-1，是这些紧密连接蛋白中的一种，其分子量约为220 kDa。 它位于细胞膜下，与其他紧密连接蛋白共同构建了细胞间连接的结构。

二抗：山羊抗兔IgG H&L （IRDye® 800CW）预吸附二抗（ab216773），山羊抗鼠IgG H&L （IRDye® 680RD）预吸附二抗（ab216776)，浓度 1/20000 稀释。 结果描述： ZO1 tight junction蛋白（绿色）， Tubulin （红色）。

2024年12月25日 · tight junction (zonula occludens) protein ZO-1,also expressed in adherens junctions,200kDa,localized in the glomerulus predominantly to points where the slit diaphragm is inserted into the lateral cell membrane of the foot process with homology to yeast guanylate kinase and Drosophila lethal discs large tumor suppressor protein TJP1

肌动球蛋白的张力通过触发ysl内的zo-1向紧密连接处聚集，从而将非紧密连接处的发生相分离的zo-1向紧密连接处转运。 而ZO-1的相分离对于这一过程是必须的。

ZO-1 makes critical, tight junction-independent contributions to Wnt signaling and mitotic spindle orientation. As a result, ZO-1 is essential for mucosal repair. We speculate that ZO-1 down-regulation may be one cause of ineffective mucosal healing in patients with IBD.

2024年5月23日 · Nature Communications - ZO-1, a cell junction protein, is essential for angiogenesis. Here the authors identify in endothelial cells unexpected associations of ZO-1 with stress granule...

Though the specific regulating mechanisms remain unclear, the ZO-1/ZONAB signaling has shown great value of research in the field of cell regeneration, stem cells and oncology. In this article, we reviewed current studies of the ZO-1/ZONAB signaling pathways relating to cell proliferation and differentiation.

2023年5月27日 · 加一抗∶兔抗 ZO-1 （1 ∶75 ），鼠抗 occludin 收集 2014 年 1 月—2017 年 10 月在中国医科大 （1 ∶100），阴性对照组中加入磷酸盐缓冲液，4 ℃ 学附属盛京医院住院的溃疡性结肠炎患者临床资料 过夜。