2024年12月25日 · XRCC6 (X-Ray Repair Cross Complementing 6) is a Protein Coding gene. Diseases associated with XRCC6 include Lupus Erythematosus and Nijmegen Breakage Syndrome . Among its related pathways are HIV Life Cycle and Infectious disease .

High Expression of XRCC6 Promotes Human Osteosarcoma Cell Proliferation through the beta-Catenin/Wnt Signaling Pathway. Data show that X-ray repair cross-complementing protein 6 ( Ku70) is found to interact with closed circular DNA. The rs2267437 in XRCC6 was associated with increased initial DSB damage.

2025年2月9日 · Title: TEX10 Promotes the Tumorigenesis and Radiotherapy Resistance of Urinary Bladder Carcinoma by Stabilizing XRCC6. The Large Nonstructural Protein (NS1) of Human Bocavirus 1 Directly Interacts with Ku70, Which Plays an Important Role in Virus Replication in Human Airway Epithelia.

2023年9月7日 · In contrast, XRCC6 expression prevents the development and progression of HCC by restoring the cellular senescence response and activating the immune network, thereby inducing efficient autophagic degradation, scavenging accumulated reactive oxygen species (ROS), reducing DNA damage, and attenuating proliferation [17, 96].

2003年6月11日 · Data from XRCC4, XRCC5, XRCC6 and XRCC7 mutant and gene analysis show that NHEJ is the predominant repair pathway in the G1 phase of cultured fibroblasts, consistent with a central role for DNA-PK in DSB recognition and binding.

2019年7月1日 · Combined deletion of Ku70 (also known as Xrcc6) and Polq in primary mouse cells induces a severe growth defect, and in HR-defective cells, POLQ expression is elevated 86,87,88. These data...

2024年3月5日 · Clinical resource with information about XRCC6, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

The XRCC6 gene encodes subunit p70 of the p70/p80 autoantigen. The p70/p80 autoantigen consists of 2 proteins of molecular mass of approximately 70,000 and 80,000 daltons that dimerize to form a 10 S DNA-binding complex. See 194364 for discussion of the gene encoding the p80 subunit.

Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA (PubMed:28712728). Interacts with HMBOX1 (PubMed: 23685356 ).

2023年8月28日 · Like its counterpart XRCC5, XRCC6 is a helicase involved in DNA repair and chromatin remodelling [579]. Also called Ku70, XRCC6 has been linked to the telomeres [158], WRN [983], and other genes putatively regulating ageing.