U.S. Food and Drug Administration

2007年4月23日 · Xcytrin (motexafin gadolinium) is an inhibitor of thioredoxin reductase and ribonucleotide reductase intended for the treatment of non-small cell lung cancer (NSCLC) patients with brain metastases. Pharmacyclics, Inc. announced the receipt of of a not-approvable letter from the U.S. Food and Drug Administration (FDA) in December 2007.

2019年5月24日 · "FDA laboratory analysis confirmed that Man Fuel Xtreme Edition contains sildenafil, dithiodesmethyl carbodenafil and desmethyl carbodenafil. Sildenafil is the active ingredient in the...

Motexafin gadolinium (proposed tradename Xcytrin) is an inhibitor of thioredoxin reductase and ribonucleotide reductase. It has been proposed as a possible chemotherapeutic agent in the …

2024年11月19日 · FDA is notifying consumers of certain products promoted for sexual enhancement and energy have been found to contain hidden ingredients and may pose a significant health risk.

2001年1月1日 · BOSTON-Combining standard radiation with a new drug called motexafin gadolinium (Xcytrin) produced substantial benefits for cancer patients with brain metastases in the lead-in phase of an ongoing phase III clinical trial, according to a report presented at the American Society for Therapeutic Radiology and Oncology (ASTRO) annual meeting.

Motexafin gadolinium (Xcytrin) is Pharmacyclics' most advanced anti-cancer product candidate, a small-molecule drug with a novel mechanism of action. Xcytrin accumulates selectively in cancer cells due to their increased rates of metabolism.

Motexafin gadolinium (MGd, Xcytrin) is an aromatic macrocycle that has a strong affinity for electrons, i.e., it is easily reduced. In the presence of oxygen, MGd accepts electrons from various cellular reducing metabolites and forms superoxide and other reactive oxygen species (ROS) by …

2020年9月14日 · In fact, the product contained prescription drugs Tadalafil and Sildenafil, the active ingredients in Viagra and Cialis. Shepard purchased the drugs from a supplier in China. He repackaged the capsules, applied his own labels and distributed them to stores in Kansas, Missouri and Colorado.