XPB (xeroderma pigmentosum type B) is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex.

2024年9月15日 · The latest motorsport images from Formula One, Formula Two, Formula Three, DTM, WRC and the World Endurance Championship.

核苷酸切除修复 （nucleotide excision repair, NER）是一种修复由紫外线和 化学致癌物 引起的各种DNA损伤的重要机制。 许多被 诊断 为着色性干皮病（xeroderma pigmentosum, XP）的患 …

2011年1月30日 · We report that triptolide covalently binds to human XPB (also known as ERCC3), a subunit of the transcription factor TFIIH, and inhibits its DNA-dependent ATPase …

2015年3月1日 · XPB is an essential core subunit of the eukaryotic basal transcription factor complex TFIIH which plays a dual role in transcription and DNA repair: 1) to facilitate the …

2012年5月10日 · Mutations in three subunits of TFIIH (XPB, XPD and p8) give rise to the autosomal recessive disorders xeroderma pigmentosum (which is sometimes associated with …

Here, we determined crystal structures of an Archaeoglobus fulgidus XPB homolog (AfXPB) that characterize two RecA-like XPB helicase domains and discover a DNA damage recognition …

2006年4月21日 · Helicases are molecular motors known to unwind double-stranded DNA. In a recent issue of Molecular Cell, Fan et al. (2006) revealed the core structure of XPB helicase, a …

The XPB and XPD subunits each contain two RecA‐like domains (ATPase/helicase); XPB has 3′‐5′ helicase activity whereas XPD has 5′‐3′ helicase activity. XPB also possesses a DRD‐like …

XPB is an essential core subunit of the eukaryotic basal transcription factor complex TFIIH which plays a dual role in transcription and DNA repair: 1) to facilitate the melting of the promoter …