Crucial roles of XCR1-expressing dendritic cells and the XCR1 …
2016年3月23日 · We showed that mice lacking XCR1 + DCs are specifically deficient in intraepithelial and lamina propria (LP) T cell populations, with remaining T cells exhibiting an …
XCR1 - Wikipedia
Cross-presenting dendritic cells (DCs) in the spleen develop into XCR1+ DCs in the small intestine, T cell zones of Peyer's patches, and T cell zones and sinuses of mesenteric lymph …
The Role of XCR1 and its Ligand XCL1 in Antigen Cross …
Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of dendritic cell (DC) known to be involved in antigen cross-presentation. This review aims to …
Cross-Presenting XCR1+ Dendritic Cells as Targets for Cancer ...
2020年2月28日 · Cross-presenting DCs are recognized for their ability to prime CD8 + T cell responses to directly induce tumor death. Consequently, they are an attractive target for next …
PD-L1+ and XCR1+ dendritic cells are region-specific ... - Nature
2021年8月13日 · Here the authors show that DC residing in the upper and lower intestines show differential PD-L1 and XCR1 expression and drive specific T cell responses to prevent gut …
Ontogenic, Phenotypic, and Functional Characterization of XCR1
We propose a simplified and consistent classification system for intestinal DC based on the expression of XCR1 and SIRPα. Keywords: dendritic cells, XCR1, Batf3, SIRPα, cross …
XCR1+ DCs are critical for T cell-mediated immunotherapy of …
Using the mouse model of chronic LCMV infection, we found that XCR1+ DCs are more resistant to infection and highly activated compared with SIRPα+ DCs. Exploiting XCR1+ DCs via Flt3L …
Cutting Edge: Expression of XCR1 Defines Mouse Lymphoid …
2011年11月1日 · In this article, we showed that LT-resident CD8α + DCs and NLT-derived CD103 + DCs specifically express XCR1 and are characterized by a unique transcriptional fingerprint, …
Selective Expression of the Chemokine Receptor XCR1 on Cross …
2009年11月20日 · In the present report, we identified XCL1 as a potent chemokine with a selective action on CD8 + DCs. These functional results are in line with extensive whole-body …
CD8+ T cells orchestrate pDC – XCR1+ dendritic cell spatial and ...
2017年2月2日 · We found that pDC accumulated at sites of CD8 + T cell antigen-driven activation in a CCR5-dependent fashion. Furthermore, activated CD8 + T cells orchestrated the local …
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