High-dimensional single-cell analysis of human natural killer cell ...
2024年7月2日 · We identified three prominent NK cell subsets in healthy human blood: NK1, NK2 and NK3, further differentiated into six distinct subgroups. Our findings delineate the molecular …
张泽民教授团队最新NK细胞泛癌症单细胞图谱文章详读 - 知乎
2023年10月18日 · 最近的研究表明，1型传统树突状细胞（cdc1s）通过分泌xcl1、xcl2和ccl5与nk细胞一起被招募到肿瘤中。 研究者的研究结果确定了通过细胞类型特异性互补策略参与 …
Discovery of specialized NK cell populations infiltrating human ...
2019年12月5日 · Tumor-infiltrating NK cells represented 7 clusters with distinct gene expression programs indicative of significant functional specialization, including cytotoxicity and …
XCL1 and XCR1 in the immune system - PubMed
XCL1, a C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses, whereas XCR1, the receptor of XCL1, is …
NK细胞图解（SNAPSHOT: Nnatural killer cells） - 知乎专栏
NK细胞还可产生一系列细胞因子（IFN-Y 、 TNF-α 、 IL-10）、生长因子（GM-CSF）、趋化因子（CCL3 、 CCL4 、 CCL5 、 XCL1）。 NK细胞还能通过与树突状细胞、巨噬细胞和T细胞相 …
NK Cells Stimulate Recruitment of cDC1 into the Tumor …
In NK cell-depleted mice, Ptgs1/Ptgs2 −/− BRAF V600E tumors expressing XCL1 grew more slowly than mock-transduced cells (Figure 5F), suggesting that XCL1-mediated recruitment of …
NK Cells Stimulate Recruitment of cDC1 into the Tumor ... - PubMed
2018年2月22日 · Here, we show that cDC1 accumulation in mouse tumors often depends on natural killer (NK) cells that produce the cDC1 chemoattractants CCL5 and XCL1. Similarly, in …
TME文献精读 | NK细胞刺激cDC1募集到肿瘤微环境中促进癌症免 …
2020年1月15日 · cDC1子集依赖于其转录因子Batf3的发育，并且可以通过选择性表达C型凝集素受体DNGR-1（又名CLEC9A）和趋化因子受体XCR1来鉴定，以及在非淋巴器官和肿瘤中 …
NK cells bring in the troops - Nature Reviews Immunology
2018年2月16日 · Intracellular flow cytometry analyses of cells from COX-deficient tumours four days after implantation showed that NK cells expressed CCL5 protein and Xcl1 mRNA, while …
Frontiers | The Role of XCR1 and its Ligand XCL1 in Antigen Cross ...
2012年2月9日 · Secretion of the chemokine XCL1 by activated NK cells specifically attracts XCR1-expressing DCs capable of antigen cross-presentation. This ensures an effective …